Detailed information of TA system TA239005

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 990552..991198
• Replicon: chromosome
• Accession: NZ_CP093913
• Organism: Aggregatibacter actinomycetemcomitans strain 9R

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JQ23
• Locus tag: MQG38_RS04740
• Protein ID: WP_005555126.1
• Coordinates: 990848..991198 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQG38_RS04735
• Protein ID: WP_005545913.1
• Coordinates: 990552..990851 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG38_RS04725	987154..987381	-	228	WP_005567423.1	hypothetical protein	-
MQG38_RS04730	987583..990516	+	2934	WP_005545915.1	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	-
MQG38_RS04735	990552..990851	-	300	WP_005545913.1	helix-turn-helix transcriptional regulator	Antitoxin
MQG38_RS04740	990848..991198	-	351	WP_005555126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQG38_RS04745	991385..992968	-	1584	WP_005545909.1	peptide chain release factor 3	-
MQG38_RS04750	993325..994152	+	828	WP_258248161.1	SDR family NAD(P)-dependent oxidoreductase	-
MQG38_RS04755	994247..995584	+	1338	WP_005545903.1	argininosuccinate synthase	-
MQG38_RS04760	995778..996023	+	246	WP_005540815.1	YgjV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13518.64 Da
• Isoelectric Point: 9.9664

>T239005 WP_005555126.1 NZ_CP093913:c991198-990848 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Nucleotide

• Length: 351 bp

>T239005 NZ_LR890562:c4643115-4642831 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11390.16 Da
• Isoelectric Point: 5.8598

>AT239005 WP_005545913.1 NZ_CP093913:c990851-990552 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRFFQI

Nucleotide

• Length: 300 bp

>AT239005 NZ_LR890562:c4643347-4643105 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: X2JQ23