Detailed information of TA system TA238997

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1445600..1446188
• Replicon: chromosome
• Accession: NZ_CP093912
• Organism: Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5D0ELR5
• Locus tag: MQG44_RS07045
• Protein ID: WP_005541261.1
• Coordinates: 1445913..1446188 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQG44_RS07040
• Protein ID: WP_005541263.1
• Coordinates: 1445600..1445896 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG44_RS07015	1440998..1442041	-	1044	WP_005541273.1	glycosyltransferase family 9 protein	-
MQG44_RS07020	1442130..1442855	+	726	WP_005541271.1	3-deoxy-D-manno-octulosonic acid kinase	-
MQG44_RS07025	1442904..1443398	-	495	WP_005541270.1	pantetheine-phosphate adenylyltransferase	-
MQG44_RS07030	1443399..1444682	-	1284	WP_005541268.1	lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase	-
MQG44_RS07035	1444781..1445542	+	762	WP_005541265.1	glycosyltransferase family 2 protein	-
MQG44_RS07040	1445600..1445896	-	297	WP_005541263.1	HigA family addiction module antitoxin	Antitoxin
MQG44_RS07045	1445913..1446188	-	276	WP_005541261.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQG44_RS07050	1446305..1447672	-	1368	WP_005541259.1	CDP-diacylglycerol--serine O-phosphatidyltransferase	-
MQG44_RS07055	1447858..1448934	+	1077	WP_005551449.1	tRNA/rRNA methyltransferase	-
MQG44_RS07060	1449001..1449261	-	261	WP_032998892.1	YfhL family 4Fe-4S dicluster ferredoxin	-
MQG44_RS07065	1449329..1450024	+	696	WP_005541254.1	ribonuclease T2 family	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-91)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-85)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10595.09 Da
• Isoelectric Point: 8.0554

>T238997 WP_005541261.1 NZ_CP093912:c1446188-1445913 [Aggregatibacter actinomycetemcomitans]
MIKSFKHKGLQAYFETGVTKGIQSAHKKKINGILDLIDNATSETEFKMFYQCHPLKGDREGIWSMKVSGNWRITFEFING
DAYILNYEDYH

Nucleotide

• Length: 276 bp

>T238997 NZ_LR890562:388091-388438 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11099.77 Da
• Isoelectric Point: 7.4038

>AT238997 WP_005541263.1 NZ_CP093912:c1445896-1445600 [Aggregatibacter actinomycetemcomitans]
MRKPAHPGEILLDGFIEPHDIKIKDLAEHLGFSRETLSRVIHGKTPMTANLALALEDAGISTARLWLSLQSNYDVWALKQ
TREASTIRPFVFSEQRFV

Nucleotide

• Length: 297 bp

>AT238997 NZ_LR890562:388438-388737 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A5D0ELR5