238994

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 746299..746865 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name higB Uniprot ID X2JU35
Locus tag MQG44_RS03465 Protein ID WP_005543444.1
Coordinates 746299..746577 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag MQG44_RS03470 Protein ID WP_005543446.1
Coordinates 746593..746865 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS03440 741857..742411 + 555 WP_005543432.1 HAD family hydrolase -
MQG44_RS03445 742577..744124 + 1548 WP_005543435.1 anthranilate synthase component 1 -
MQG44_RS03450 744135..744725 + 591 WP_005543437.1 aminodeoxychorismate/anthranilate synthase component II -
MQG44_RS03455 744799..745191 + 393 WP_005543439.1 tautomerase family protein -
MQG44_RS03460 745203..746204 + 1002 WP_005543441.1 anthranilate phosphoribosyltransferase -
MQG44_RS03465 746299..746577 + 279 WP_005543444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG44_RS03470 746593..746865 + 273 WP_005543446.1 HigA family addiction module antitoxin Antitoxin
MQG44_RS03475 746874..748304 + 1431 WP_005543449.1 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF -
MQG44_RS03480 748585..748731 + 147 Protein_669 hydrogenase -
MQG44_RS03485 748761..749036 + 276 WP_005543453.1 hydrogenase maturation factor HybG -
MQG44_RS03490 749157..749534 - 378 WP_005543455.1 hypothetical protein -
MQG44_RS03495 749509..749700 - 192 WP_005553960.1 hypothetical protein -
MQG44_RS03500 750061..750327 + 267 WP_005543457.1 oxaloacetate decarboxylase subunit gamma -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-92)

Antitoxin

(1-79)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10490.95 Da        Isoelectric Point: 9.5983

>T238994 WP_005543444.1 NZ_CP093912:746299-746577 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Download         Length: 279 bp

>T238994 NZ_LR890556:4648028-4648438 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10138.74 Da        Isoelectric Point: 7.3169

>AT238994 WP_005543446.1 NZ_CP093912:746593-746865 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Download         Length: 273 bp

>AT238994 NZ_LR890556:4647781-4648047 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X2JU35


Antitoxin

Source ID Structure

References