Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 746299..746865 | Replicon | chromosome |
Accession | NZ_CP093912 | ||
Organism | Aggregatibacter actinomycetemcomitans strain 14R |
Toxin (Protein)
Gene name | higB | Uniprot ID | X2JU35 |
Locus tag | MQG44_RS03465 | Protein ID | WP_005543444.1 |
Coordinates | 746299..746577 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | graA | Uniprot ID | - |
Locus tag | MQG44_RS03470 | Protein ID | WP_005543446.1 |
Coordinates | 746593..746865 (+) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MQG44_RS03440 | 741857..742411 | + | 555 | WP_005543432.1 | HAD family hydrolase | - |
MQG44_RS03445 | 742577..744124 | + | 1548 | WP_005543435.1 | anthranilate synthase component 1 | - |
MQG44_RS03450 | 744135..744725 | + | 591 | WP_005543437.1 | aminodeoxychorismate/anthranilate synthase component II | - |
MQG44_RS03455 | 744799..745191 | + | 393 | WP_005543439.1 | tautomerase family protein | - |
MQG44_RS03460 | 745203..746204 | + | 1002 | WP_005543441.1 | anthranilate phosphoribosyltransferase | - |
MQG44_RS03465 | 746299..746577 | + | 279 | WP_005543444.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MQG44_RS03470 | 746593..746865 | + | 273 | WP_005543446.1 | HigA family addiction module antitoxin | Antitoxin |
MQG44_RS03475 | 746874..748304 | + | 1431 | WP_005543449.1 | bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF | - |
MQG44_RS03480 | 748585..748731 | + | 147 | Protein_669 | hydrogenase | - |
MQG44_RS03485 | 748761..749036 | + | 276 | WP_005543453.1 | hydrogenase maturation factor HybG | - |
MQG44_RS03490 | 749157..749534 | - | 378 | WP_005543455.1 | hypothetical protein | - |
MQG44_RS03495 | 749509..749700 | - | 192 | WP_005553960.1 | hypothetical protein | - |
MQG44_RS03500 | 750061..750327 | + | 267 | WP_005543457.1 | oxaloacetate decarboxylase subunit gamma | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10490.95 Da Isoelectric Point: 9.5983
>T238994 WP_005543444.1 NZ_CP093912:746299-746577 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH
Download Length: 279 bp
>T238994 NZ_LR890556:4648028-4648438 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10138.74 Da Isoelectric Point: 7.3169
>AT238994 WP_005543446.1 NZ_CP093912:746593-746865 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN
Download Length: 273 bp
>AT238994 NZ_LR890556:4647781-4648047 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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