Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 575948..576594 Replicon chromosome
Accession NZ_CP093912
Organism Aggregatibacter actinomycetemcomitans strain 14R

Toxin (Protein)


Gene name higB Uniprot ID A0A5D0EMT1
Locus tag MQG44_RS02710 Protein ID WP_005552065.1
Coordinates 575948..576298 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID X2JT85
Locus tag MQG44_RS02715 Protein ID WP_005540827.1
Coordinates 576295..576594 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG44_RS02690 571133..571378 - 246 WP_005540815.1 YgjV family protein -
MQG44_RS02695 571569..572906 - 1338 WP_005540817.1 argininosuccinate synthase -
MQG44_RS02700 572994..573821 - 828 WP_005594959.1 hypothetical protein -
MQG44_RS02705 574178..575761 + 1584 WP_005540820.1 peptide chain release factor 3 -
MQG44_RS02710 575948..576298 + 351 WP_005552065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQG44_RS02715 576295..576594 + 300 WP_005540827.1 helix-turn-helix transcriptional regulator Antitoxin
MQG44_RS02720 576630..579563 - 2934 WP_005594956.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13508.60 Da        Isoelectric Point: 9.9664

>T238992 WP_005552065.1 NZ_CP093912:575948-576298 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQSIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Download         Length: 351 bp

>T238992 NZ_LR890556:4189276-4189644 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11342.12 Da        Isoelectric Point: 5.8598

>AT238992 WP_005540827.1 NZ_CP093912:576295-576594 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRVFQI

Download         Length: 300 bp

>AT238992 NZ_LR890556:4189058-4189279 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D0EMT1

Antitoxin

Source ID Structure
AlphaFold DB X2JT85

References