Detailed information of TA system TA238983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1365835..1366481
• Replicon: chromosome
• Accession: NZ_CP093911
• Organism: Aggregatibacter actinomycetemcomitans strain 16R

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JQ23
• Locus tag: MQG37_RS06900
• Protein ID: WP_005555126.1
• Coordinates: 1366131..1366481 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQG37_RS06895
• Protein ID: WP_005545913.1
• Coordinates: 1365835..1366134 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG37_RS06885	1362437..1362664	-	228	WP_005567423.1	hypothetical protein	-
MQG37_RS06890	1362866..1365799	+	2934	WP_005545915.1	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	-
MQG37_RS06895	1365835..1366134	-	300	WP_005545913.1	helix-turn-helix transcriptional regulator	Antitoxin
MQG37_RS06900	1366131..1366481	-	351	WP_005555126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQG37_RS06905	1366668..1368251	-	1584	WP_005545909.1	peptide chain release factor 3	-
MQG37_RS06910	1368608..1369435	+	828	WP_005545905.1	hypothetical protein	-
MQG37_RS06915	1369530..1370867	+	1338	WP_005545903.1	argininosuccinate synthase	-
MQG37_RS06920	1371061..1371306	+	246	WP_005540815.1	YgjV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13518.64 Da
• Isoelectric Point: 9.9664

>T238983 WP_005555126.1 NZ_CP093911:c1366481-1366131 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Nucleotide

• Length: 351 bp

>T238983 NZ_LR890554:c5291261-5290878 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11390.16 Da
• Isoelectric Point: 5.8598

>AT238983 WP_005545913.1 NZ_CP093911:c1366134-1365835 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRFFQI

Nucleotide

• Length: 300 bp

>AT238983 NZ_LR890554:c5291503-5291261 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATACCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: X2JQ23