Detailed information of TA system TA238973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1240490..1241136
• Replicon: chromosome
• Accession: NZ_CP093910
• Organism: Aggregatibacter actinomycetemcomitans strain 27R

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JQ23
• Locus tag: MQG43_RS06310
• Protein ID: WP_005555126.1
• Coordinates: 1240490..1240840 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQG43_RS06315
• Protein ID: WP_005545913.1
• Coordinates: 1240837..1241136 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQG43_RS06290	1235665..1235910	-	246	WP_005540815.1	YgjV family protein	-
MQG43_RS06295	1236104..1237441	-	1338	WP_005545903.1	argininosuccinate synthase	-
MQG43_RS06300	1237536..1238363	-	828	WP_258271147.1	SDR family NAD(P)-dependent oxidoreductase	-
MQG43_RS06305	1238720..1240303	+	1584	WP_258271148.1	peptide chain release factor 3	-
MQG43_RS06310	1240490..1240840	+	351	WP_005555126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQG43_RS06315	1240837..1241136	+	300	WP_005545913.1	helix-turn-helix transcriptional regulator	Antitoxin
MQG43_RS06320	1241172..1244105	-	2934	WP_258271149.1	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	-
MQG43_RS06325	1244307..1244534	+	228	WP_005567423.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13518.64 Da
• Isoelectric Point: 9.9664

>T238973 WP_005555126.1 NZ_CP093910:1240490-1240840 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Nucleotide

• Length: 351 bp

>T238973 NZ_LR890554:199829-200314 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11390.16 Da
• Isoelectric Point: 5.8598

>AT238973 WP_005545913.1 NZ_CP093910:1240837-1241136 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRFFQI

Nucleotide

• Length: 300 bp

>AT238973 NZ_LR890554:199575-199841 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: X2JQ23