Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1724896..1725313 Replicon chromosome
Accession NC_012846
Organism Bartonella grahamii as4aup

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag BGR_RS10520 Protein ID WP_081429737.1
Coordinates 1725155..1725313 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A336NAP0
Locus tag BGR_RS07340 Protein ID WP_026500656.1
Coordinates 1724896..1725153 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGR_RS07325 1722131..1723891 - 1761 WP_015856205.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
BGR_RS07330 1723884..1724063 - 180 WP_041581390.1 hypothetical protein -
BGR_RS07335 1724318..1724690 + 373 Protein_1421 hypothetical protein -
BGR_RS07340 1724896..1725153 + 258 WP_026500656.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BGR_RS10520 1725155..1725313 + 159 WP_081429737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
BGR_RS10525 1725329..1725427 + 99 WP_081429759.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
BGR_RS07345 1726488..1727321 + 834 WP_015856203.1 hypothetical protein -
BGR_RS07350 1727405..1727983 + 579 WP_041581437.1 hypothetical protein -
BGR_RS07355 1728094..1728873 + 780 WP_015856741.1 hypothetical protein -
BGR_RS07360 1729808..1730302 - 495 WP_041581587.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-52)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-81)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6256.45 Da        Isoelectric Point: 11.1374

>T23897 WP_081429737.1 NC_012846:1725155-1725313 [Bartonella grahamii as4aup]
MLIPVRSRQFKRDVRKAEKRSKNMNKLRTLLSLLIEEKPLPRHYCDHPLKGD

Download         Length: 159 bp

>T23897 NC_012846:1725155-1725313 [Bartonella grahamii as4aup]
ATGCTGATACCTGTTCGCTCGAGACAATTTAAACGTGACGTGCGCAAGGCGGAAAAACGCAGTAAAAATATGAATAAGCT
GCGTACACTATTAAGTCTTCTAATTGAAGAAAAGCCATTACCAAGACATTACTGTGATCATCCACTAAAAGGCGATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9450.25 Da        Isoelectric Point: 10.5473

>AT23897 WP_026500656.1 NC_012846:1724896-1725153 [Bartonella grahamii as4aup]
MKADSVVRARIPAKMKKQAMITLERMGLSASDLIRITFLRVAEEGCLPFELKVPNSVTRKAIKELDEGKGKTFKNADALF
KDLGI

Download         Length: 258 bp

>AT23897 NC_012846:1724896-1725153 [Bartonella grahamii as4aup]
ATGAAAGCCGATTCTGTTGTTCGCGCTCGCATTCCTGCTAAAATGAAAAAACAAGCGATGATTACTTTAGAACGCATGGG
ATTAAGTGCATCAGATCTTATCCGCATAACATTTTTGCGTGTCGCTGAAGAAGGTTGTTTGCCTTTTGAGCTTAAAGTAC
CTAATAGTGTCACACGTAAAGCTATAAAGGAATTAGATGAAGGTAAAGGTAAGACATTTAAAAACGCTGATGCCCTTTTT
AAGGATTTAGGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A336NAP0

References