Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3502825..3503427 Replicon chromosome
Accession NZ_CP093548
Organism Escherichia coli strain YL03

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag MPJ80_RS17060 Protein ID WP_000897305.1
Coordinates 3502825..3503136 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MPJ80_RS17065 Protein ID WP_000356395.1
Coordinates 3503137..3503427 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPJ80_RS17035 (3497866) 3497866..3498303 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
MPJ80_RS17040 (3498348) 3498348..3499289 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
MPJ80_RS17045 (3499705) 3499705..3500592 + 888 Protein_3336 hypothetical protein -
MPJ80_RS17050 (3500605) 3500605..3501519 + 915 WP_077634137.1 transposase -
MPJ80_RS17055 (3501688) 3501688..3502596 - 909 WP_001306651.1 alpha/beta hydrolase -
MPJ80_RS17060 (3502825) 3502825..3503136 + 312 WP_000897305.1 hypothetical protein Toxin
MPJ80_RS17065 (3503137) 3503137..3503427 + 291 WP_000356395.1 NadS family protein Antitoxin
MPJ80_RS17070 (3503786) 3503786..3504064 + 279 WP_001306650.1 hypothetical protein -
MPJ80_RS17075 (3504483) 3504483..3504701 + 219 WP_001295676.1 CopG family transcriptional regulator -
MPJ80_RS17080 (3504920) 3504920..3505162 + 243 WP_021523315.1 hypothetical protein -
MPJ80_RS17085 (3505344) 3505344..3506273 - 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
MPJ80_RS17090 (3506270) 3506270..3506905 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
MPJ80_RS17095 (3506902) 3506902..3507804 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T238878 WP_000897305.1 NZ_CP093548:3502825-3503136 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T238878 NZ_LR890519:28345-28503 [Klebsiella pneumoniae]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10869.46 Da        Isoelectric Point: 10.8907

>AT238878 WP_000356395.1 NZ_CP093548:3503137-3503427 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRHPSRTFEVDAMKIKEIRRASGLSQSKFAELISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT238878 NZ_LR890519:28234-28299 [Klebsiella pneumoniae]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References