Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 87499..88151 Replicon plasmid pRS1931m
Accession NZ_CP093536
Organism Ralstonia pseudosolanacearum strain SL1931

Toxin (Protein)


Gene name higB Uniprot ID A0A0S4U5H4
Locus tag MNY32_RS17940 Protein ID WP_028861315.1
Coordinates 87499..87843 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MNY32_RS17945 Protein ID WP_020425351.1
Coordinates 87840..88151 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY32_RS17925 (MNY32_17925) 83195..84358 - 1164 WP_016726526.1 2-methylcitrate synthase -
MNY32_RS17930 (MNY32_17930) 84410..85306 - 897 WP_071092368.1 methylisocitrate lyase -
MNY32_RS17935 (MNY32_17935) 85499..87448 + 1950 WP_023470006.1 propionate catabolism operon regulatory protein PrpR -
MNY32_RS17940 (MNY32_17940) 87499..87843 + 345 WP_028861315.1 hypothetical protein Toxin
MNY32_RS17945 (MNY32_17945) 87840..88151 + 312 WP_020425351.1 transcriptional regulator Antitoxin
MNY32_RS17950 (MNY32_17950) 88291..89100 - 810 WP_071623829.1 DUF2242 domain-containing protein -
MNY32_RS17955 (MNY32_17955) 89744..90319 - 576 WP_071623824.1 hypothetical protein -
MNY32_RS17960 (MNY32_17960) 90732..90848 + 117 Protein_80 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - motA / cheW / cheB / cheY / adeG / htpB / acrB / fliI / fliG / fliM / flgG / flgC / cyaB 1..2075606 2075606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13276.03 Da        Isoelectric Point: 9.3395

>T238841 WP_028861315.1 NZ_CP093536:87499-87843 [Ralstonia pseudosolanacearum]
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIYYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

>T238841 NZ_LR890504:69663-69812 [Klebsiella pneumoniae]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11619.65 Da        Isoelectric Point: 10.7132

>AT238841 WP_020425351.1 NZ_CP093536:87840-88151 [Ralstonia pseudosolanacearum]
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT238841 NZ_LR890504:c69618-69559 [Klebsiella pneumoniae]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4U5H4

Antitoxin

Source ID Structure

References