Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1949896..1950523 Replicon chromosome
Accession NC_012779
Organism Edwardsiella ictaluri 93-146

Toxin (Protein)


Gene name higB Uniprot ID A0A411H7J1
Locus tag NT01EI_RS08845 Protein ID WP_015871332.1
Coordinates 1949896..1950225 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C5BBM8
Locus tag NT01EI_RS08850 Protein ID WP_015871333.1
Coordinates 1950215..1950523 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT01EI_RS08810 1945120..1945671 - 552 WP_015871324.1 glycoside hydrolase family 108 protein -
NT01EI_RS08815 1945674..1946021 - 348 WP_035608895.1 phage holin, lambda family -
NT01EI_RS08820 1946105..1946434 - 330 WP_015871326.1 type II toxin-antitoxin system RelE/ParE family toxin -
NT01EI_RS08825 1946409..1946639 - 231 WP_015871327.1 ParD-like family protein -
NT01EI_RS18110 1946771..1947015 - 245 Protein_1746 transposase -
NT01EI_RS08830 1947121..1947939 - 819 WP_015871329.1 hypothetical protein -
NT01EI_RS08835 1948028..1948543 - 516 WP_034165088.1 hypothetical protein -
NT01EI_RS08840 1948884..1949447 - 564 Protein_1749 Rha family transcriptional regulator -
NT01EI_RS08845 1949896..1950225 + 330 WP_015871332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NT01EI_RS08850 1950215..1950523 + 309 WP_015871333.1 helix-turn-helix transcriptional regulator Antitoxin
NT01EI_RS08855 1950626..1951138 + 513 WP_015871334.1 DUF2442 domain-containing protein -
NT01EI_RS18120 1951505..1952014 - 510 WP_071525693.1 hypothetical protein -
NT01EI_RS18125 1952015..1953055 - 1041 WP_015871335.1 hypothetical protein -
NT01EI_RS08860 1953200..1953499 - 300 WP_015871336.1 DUF1364 domain-containing protein -
NT01EI_RS08865 1953502..1954146 - 645 WP_015871337.1 DUF1367 family protein -
NT01EI_RS08870 1954256..1954603 - 348 WP_015871339.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1904680..1974943 70263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12771.78 Da        Isoelectric Point: 9.6247

>T23884 WP_015871332.1 NC_012779:1949896-1950225 [Edwardsiella ictaluri 93-146]
MNYTIEYYSEEVRLEVDQLPMGMRVRYQHLVERMEIYGSNLGEPHTSPFGDGLFELRIKGSDGIARVFYCTLTGKRIVML
HSFIKKTQKTPSAERKKAETRMKEVKHGW

Download         Length: 330 bp

>T23884 NC_012779:1949896-1950225 [Edwardsiella ictaluri 93-146]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCAGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11207.86 Da        Isoelectric Point: 8.5371

>AT23884 WP_015871333.1 NC_012779:1950215-1950523 [Edwardsiella ictaluri 93-146]
MAGKRTPPTMTHDEMAAKWMEDPAFKAEYDAIEEEYALLDEMLAARKNAGLTQAQVAERMGTKATAITRMESNLASGQSG
PSFATLKKFAHATGKKLQIRFV

Download         Length: 309 bp

>AT23884 NC_012779:1950215-1950523 [Edwardsiella ictaluri 93-146]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCAGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGGCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H7J1

Antitoxin

Source ID Structure
AlphaFold DB C5BBM8

References