Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1773658..1774276 Replicon chromosome
Accession NZ_CP093528
Organism Shinella zoogloeoides strain XJ20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MOE34_RS09065 Protein ID WP_072461974.1
Coordinates 1773658..1773954 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MOE34_RS09070 Protein ID WP_072461975.1
Coordinates 1773968..1774276 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOE34_RS09045 1768879..1771848 + 2970 WP_242223021.1 Ti-type conjugative transfer relaxase TraA -
MOE34_RS09050 1771929..1772798 - 870 WP_242223024.1 OST-HTH/LOTUS domain-containing protein -
MOE34_RS09055 1773120..1773347 + 228 WP_072461972.1 AlpA family phage regulatory protein -
MOE34_RS09060 1773337..1773594 + 258 WP_072461973.1 hypothetical protein -
MOE34_RS09065 1773658..1773954 + 297 WP_072461974.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOE34_RS09070 1773968..1774276 + 309 WP_072461975.1 HigA family addiction module antitoxin Antitoxin
MOE34_RS09075 1774335..1775957 + 1623 WP_242223025.1 recombinase family protein -
MOE34_RS09085 1776189..1776638 - 450 WP_242223027.1 universal stress protein -
MOE34_RS09090 1776884..1778098 - 1215 WP_242223029.1 lipid-A-disaccharide synthase -
MOE34_RS09095 1778095..1778973 - 879 WP_242223031.1 UDP-2,3-diacylglucosamine diphosphatase LpxI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11603.03 Da        Isoelectric Point: 6.7266

>T238833 WP_072461974.1 NZ_CP093528:1773658-1773954 [Shinella zoogloeoides]
VIVGFRDGWLRAFFVDDVRSRNIPSDLEARLFRKLQMIDDAVTDQDLRVPPSNHFEKLRGNLAGFHSIRVNQQWRLIFRW
DGERGEADGIYLDDHSYR

Download         Length: 297 bp

>T238833 NZ_LR890500:3701333-3701716 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11521.30 Da        Isoelectric Point: 10.7239

>AT238833 WP_072461975.1 NZ_CP093528:1773968-1774276 [Shinella zoogloeoides]
MLTTKRKPATVGEILTEEFMQPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGTSPDFWLNVQRRSDLW
EVMNTPKERERVERARPLQNAA

Download         Length: 309 bp

>AT238833 NZ_LR890500:3701091-3701333 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References