Detailed information of TA system TA238826

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2448059..2448243
• Replicon: chromosome
• Accession: NZ_CP093527
• Organism: Staphylococcus aureus strain 697R

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MPF55_RS12085
• Protein ID: WP_000482647.1
• Coordinates: 2448136..2448243 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2448059..2448119 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF55_RS12070	2443569..2443736	-	168	WP_031845053.1	hypothetical protein	-
MPF55_RS12075	2443967..2445700	-	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
MPF55_RS12080	2445776..2447488	-	1713	WP_001064821.1	ABC transporter ATP-binding protein	-
-	2448059..2448119	+	61	-	-	Antitoxin
MPF55_RS12085	2448136..2448243	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MPF55_RS12090	2448376..2448762	-	387	WP_000779353.1	flippase GtxA	-
MPF55_RS12095	2449030..2450172	+	1143	WP_001176863.1	glycerate kinase	-
MPF55_RS12100	2450232..2450891	+	660	WP_000831298.1	membrane protein	-
MPF55_RS12105	2451074..2452285	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
MPF55_RS12110	2452408..2452881	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T238826 WP_000482647.1 NZ_CP093527:c2448243-2448136 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T238826 NZ_LR890493:c4677475-4677191 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT238826 NZ_CP093527:2448059-2448119 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin