Detailed information of TA system TA238820

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 809423..809761
• Replicon: chromosome
• Accession: NZ_CP093527
• Organism: Staphylococcus aureus strain 697R

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MPF55_RS04085
• Protein ID: WP_011447039.1
• Coordinates: 809423..809599 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	809587..809761 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF55_RS04065	804658..808443	+	3786	WP_044557000.1	phage tail spike protein	-
MPF55_RS04070	808433..808585	+	153	WP_001153681.1	hypothetical protein	-
MPF55_RS04075	808632..808919	+	288	WP_001040261.1	hypothetical protein	-
MPF55_RS04080	808977..809273	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
MPF55_RS04085	809423..809599	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	809587..809761	-	175	-	-	Antitoxin
MPF55_RS04095	809811..810065	+	255	WP_000611512.1	phage holin	-
MPF55_RS04100	810077..810832	+	756	WP_000861038.1	CHAP domain-containing protein	-
MPF55_RS04105	811023..811514	+	492	WP_000919350.1	staphylokinase	-
MPF55_RS04110	812164..812499	+	336	Protein_764	SH3 domain-containing protein	-
MPF55_RS04115	812594..813043	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
MPF55_RS04120	813728..814078	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
MPF55_RS04125	814131..814391	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn / hysA	766415..826743	60328

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T238820 WP_011447039.1 NZ_CP093527:809423-809599 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T238820 NZ_LR890493:800635-801045 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT238820 NZ_CP093527:c809761-809587 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin