Detailed information of TA system TA238814

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 509718..509997
• Replicon: chromosome
• Accession: NZ_CP093527
• Organism: Staphylococcus aureus strain 697R

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MPF55_RS02320
• Protein ID: WP_001802298.1
• Coordinates: 509718..509822 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	509818..509997 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPF55_RS02290	505112..505894	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
MPF55_RS02295	505962..506819	+	858	WP_000370919.1	HAD family hydrolase	-
MPF55_RS02305	507514..507606	-	93	WP_031844941.1	hypothetical protein	-
MPF55_RS02310	507895..509031	+	1137	Protein_447	SAP domain-containing protein	-
MPF55_RS02315	509074..509557	+	484	Protein_448	recombinase family protein	-
MPF55_RS02320	509718..509822	+	105	WP_001802298.1	hypothetical protein	Toxin
-	509818..509997	-	180	-	-	Antitoxin
MPF55_RS02330	510271..511362	-	1092	WP_000495695.1	hypothetical protein	-
MPF55_RS02335	511628..512605	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
MPF55_RS02340	512607..512927	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MPF55_RS02345	513079..513744	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T238814 WP_001802298.1 NZ_CP093527:509718-509822 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T238814 NZ_LR890490:c4953685-4953401 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT238814 NZ_CP093527:c509997-509818 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin