Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 326560..327146 Replicon chromosome
Accession NZ_CP093476
Organism Klebsiella pneumoniae strain VA569

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag MO417_RS01520 Protein ID WP_002920800.1
Coordinates 326778..327146 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag MO417_RS01515 Protein ID WP_002920802.1
Coordinates 326560..326781 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO417_RS01495 (MO417_01495) 322717..323643 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MO417_RS01500 (MO417_01500) 323640..324917 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
MO417_RS01505 (MO417_01505) 324914..325681 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MO417_RS01510 (MO417_01510) 325683..326396 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MO417_RS01515 (MO417_01515) 326560..326781 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MO417_RS01520 (MO417_01520) 326778..327146 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MO417_RS01525 (MO417_01525) 327419..328735 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MO417_RS01530 (MO417_01530) 328842..329729 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MO417_RS01535 (MO417_01535) 329726..330571 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MO417_RS01540 (MO417_01540) 330573..331643 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 323640..332380 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T238690 WP_002920800.1 NZ_CP093476:326778-327146 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T238690 NZ_LR890446:c4705533-4705192 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTATCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATAACTTTGGCCGATGCCGTTAACTTTTTGGTAGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGATTC
AACTGGCAGGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT238690 WP_002920802.1 NZ_CP093476:326560-326781 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT238690 NZ_LR890446:c4705895-4705554 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTAAAATGGGGACTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTACACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTTTCACCCTGTACCACAATGGTTTCTCCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References