Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4769190..4769944 | Replicon | chromosome |
| Accession | NZ_CP093445 | ||
| Organism | Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | MOV10_RS23010 | Protein ID | WP_000558166.1 |
| Coordinates | 4769190..4769501 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MOV10_RS23015 | Protein ID | WP_001259010.1 |
| Coordinates | 4769498..4769944 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOV10_RS22980 (4764848) | 4764848..4765750 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| MOV10_RS22985 (4765747) | 4765747..4766382 | + | 636 | WP_061380386.1 | formate dehydrogenase cytochrome b556 subunit | - |
| MOV10_RS22990 (4766379) | 4766379..4767308 | + | 930 | WP_242105529.1 | formate dehydrogenase accessory protein FdhE | - |
| MOV10_RS22995 (4767355) | 4767355..4767645 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| MOV10_RS23000 (4767646) | 4767646..4767957 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| MOV10_RS23005 (4768175) | 4768175..4769104 | + | 930 | WP_023207327.1 | alpha/beta hydrolase | - |
| MOV10_RS23010 (4769190) | 4769190..4769501 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MOV10_RS23015 (4769498) | 4769498..4769944 | + | 447 | WP_001259010.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| MOV10_RS23020 (4769959) | 4769959..4770900 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| MOV10_RS23025 (4770945) | 4770945..4771382 | - | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| MOV10_RS23030 (4771379) | 4771379..4772251 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| MOV10_RS23035 (4772245) | 4772245..4772844 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| MOV10_RS23040 (4773035) | 4773035..4773838 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| MOV10_RS23045 (4773872) | 4773872..4774768 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T238611 WP_000558166.1 NZ_CP093445:4769190-4769501 [Salmonella enterica subsp. enterica serovar Abeokuta]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T238611 NZ_LR890410:4101031-4101333 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16735.03 Da Isoelectric Point: 6.0016
>AT238611 WP_001259010.1 NZ_CP093445:4769498-4769944 [Salmonella enterica subsp. enterica serovar Abeokuta]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEETPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT238611 NZ_LR890410:4101369-4101710 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|