Detailed information of TA system TA238610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4767355..4767957
• Replicon: chromosome
• Accession: NZ_CP093445
• Organism: Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: MOV10_RS23000
• Protein ID: WP_001159630.1
• Coordinates: 4767646..4767957 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOV10_RS22995
• Protein ID: WP_000362050.1
• Coordinates: 4767355..4767645 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV10_RS22980 (4764848)	4764848..4765750	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
MOV10_RS22985 (4765747)	4765747..4766382	+	636	WP_061380386.1	formate dehydrogenase cytochrome b556 subunit	-
MOV10_RS22990 (4766379)	4766379..4767308	+	930	WP_242105529.1	formate dehydrogenase accessory protein FdhE	-
MOV10_RS22995 (4767355)	4767355..4767645	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
MOV10_RS23000 (4767646)	4767646..4767957	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
MOV10_RS23005 (4768175)	4768175..4769104	+	930	WP_023207327.1	alpha/beta hydrolase	-
MOV10_RS23010 (4769190)	4769190..4769501	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOV10_RS23015 (4769498)	4769498..4769944	+	447	WP_001259010.1	type II toxin-antitoxin system HigA family antitoxin	-
MOV10_RS23020 (4769959)	4769959..4770900	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MOV10_RS23025 (4770945)	4770945..4771382	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
MOV10_RS23030 (4771379)	4771379..4772251	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOV10_RS23035 (4772245)	4772245..4772844	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T238610 WP_001159630.1 NZ_CP093445:c4767957-4767646 [Salmonella enterica subsp. enterica serovar Abeokuta]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T238610 NZ_LR890410:c4073246-4073028 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT238610 WP_000362050.1 NZ_CP093445:c4767645-4767355 [Salmonella enterica subsp. enterica serovar Abeokuta]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT238610 NZ_LR890410:c4073646-4073272 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A0R9NS64