Detailed information of TA system TA238579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4687719..4688321
• Replicon: chromosome
• Accession: NZ_CP093411
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: MOP53_RS22830
• Protein ID: WP_001159632.1
• Coordinates: 4688010..4688321 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOP53_RS22825
• Protein ID: WP_000362051.1
• Coordinates: 4687719..4688009 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP53_RS22810 (4685212)	4685212..4686114	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOP53_RS22815 (4686111)	4686111..4686746	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOP53_RS22820 (4686743)	4686743..4687672	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MOP53_RS22825 (4687719)	4687719..4688009	-	291	WP_000362051.1	NadS family protein	Antitoxin
MOP53_RS22830 (4688010)	4688010..4688321	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
MOP53_RS22835 (4688539)	4688539..4689468	+	930	WP_001127697.1	alpha/beta hydrolase	-
MOP53_RS22840 (4689554)	4689554..4689865	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOP53_RS22845 (4689862)	4689862..4690308	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MOP53_RS22850 (4690323)	4690323..4691264	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MOP53_RS22855 (4691309)	4691309..4691746	-	438	WP_000560973.1	D-aminoacyl-tRNA deacylase	-
MOP53_RS22860 (4691743)	4691743..4692615	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOP53_RS22865 (4692609)	4692609..4693208	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T238579 WP_001159632.1 NZ_CP093411:c4688321-4688010 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T238579 NZ_LR890405:c2668079-2667903 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10957.57 Da
• Isoelectric Point: 10.6525

>AT238579 WP_000362051.1 NZ_CP093411:c4688009-4687719 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT238579 NZ_LR890405:c2667857-2667441 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31