Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2741881..2742608 | Replicon | chromosome |
| Accession | NZ_CP093411 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R18.0246 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V7IQW2 |
| Locus tag | MOP53_RS13360 | Protein ID | WP_000558158.1 |
| Coordinates | 2741881..2742192 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MOP53_RS13365 | Protein ID | WP_000561389.1 |
| Coordinates | 2742189..2742608 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOP53_RS13325 (2737048) | 2737048..2737770 | - | 723 | WP_000182066.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
| MOP53_RS13330 (2738455) | 2738455..2738850 | + | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| MOP53_RS13335 (2739179) | 2739179..2739655 | + | 477 | WP_000030944.1 | hypothetical protein | - |
| MOP53_RS13340 (2739765) | 2739765..2739959 | + | 195 | WP_023134800.1 | hypothetical protein | - |
| MOP53_RS13345 (2740322) | 2740322..2741104 | + | 783 | WP_001747695.1 | DUF2971 domain-containing protein | - |
| MOP53_RS13350 (2741158) | 2741158..2741373 | - | 216 | WP_001747696.1 | hypothetical protein | - |
| MOP53_RS13355 (2741403) | 2741403..2741702 | - | 300 | WP_000775225.1 | hypothetical protein | - |
| MOP53_RS13360 (2741881) | 2741881..2742192 | + | 312 | WP_000558158.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MOP53_RS13365 (2742189) | 2742189..2742608 | + | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| MOP53_RS13370 (2742864) | 2742864..2743358 | + | 495 | WP_016419152.1 | glycosyltransferase | - |
| MOP53_RS25360 (2743355) | 2743355..2743513 | + | 159 | WP_023165344.1 | lipopolysaccharide 1,2-N-acetylglucosaminetransferase | - |
| MOP53_RS13375 (2743749) | 2743749..2744168 | - | 420 | WP_000354404.1 | GNAT family N-acetyltransferase | - |
| MOP53_RS13380 (2744539) | 2744539..2744808 | + | 270 | WP_077905753.1 | hypothetical protein | - |
| MOP53_RS13385 (2744974) | 2744974..2745114 | + | 141 | WP_000489598.1 | hypothetical protein | - |
| MOP53_RS13390 (2745260) | 2745260..2745802 | - | 543 | Protein_2629 | IS256 family transposase | - |
| MOP53_RS13395 (2745822) | 2745822..2745914 | - | 93 | WP_231923105.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2745260..2745937 | 677 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12398.19 Da Isoelectric Point: 10.0279
>T238563 WP_000558158.1 NZ_CP093411:2741881-2742192 [Salmonella enterica subsp. enterica serovar Agona]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T238563 NZ_LR890395:c4634064-4633531 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT238563 WP_000561389.1 NZ_CP093411:2742189-2742608 [Salmonella enterica subsp. enterica serovar Agona]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT238563 NZ_LR890395:c4634341-4634075 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|