Detailed information of TA system TA238556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4682789..4683391
• Replicon: chromosome
• Accession: NZ_CP093407
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R19.0144

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: MOP55_RS22795
• Protein ID: WP_001159632.1
• Coordinates: 4683080..4683391 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOP55_RS22790
• Protein ID: WP_000362051.1
• Coordinates: 4682789..4683079 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP55_RS22775 (4680282)	4680282..4681184	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOP55_RS22780 (4681181)	4681181..4681816	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOP55_RS22785 (4681813)	4681813..4682742	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MOP55_RS22790 (4682789)	4682789..4683079	-	291	WP_000362051.1	NadS family protein	Antitoxin
MOP55_RS22795 (4683080)	4683080..4683391	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
MOP55_RS22800 (4683609)	4683609..4684538	+	930	WP_001127697.1	alpha/beta hydrolase	-
MOP55_RS22805 (4684624)	4684624..4684935	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOP55_RS22810 (4684932)	4684932..4685378	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MOP55_RS22815 (4685393)	4685393..4686334	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MOP55_RS22820 (4686379)	4686379..4686816	-	438	WP_000560973.1	D-aminoacyl-tRNA deacylase	-
MOP55_RS22825 (4686813)	4686813..4687685	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOP55_RS22830 (4687679)	4687679..4688278	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T238556 WP_001159632.1 NZ_CP093407:c4683391-4683080 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T238556 NZ_LR890395:324617-324985 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10957.57 Da
• Isoelectric Point: 10.6525

>AT238556 WP_000362051.1 NZ_CP093407:c4683079-4682789 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT238556 NZ_LR890395:324399-324620 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31