Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2769315..2770042 | Replicon | chromosome |
| Accession | NZ_CP093407 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R19.0144 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V7IQW2 |
| Locus tag | MOP55_RS13555 | Protein ID | WP_000558158.1 |
| Coordinates | 2769315..2769626 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MOP55_RS13560 | Protein ID | WP_000561389.1 |
| Coordinates | 2769623..2770042 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOP55_RS13520 (2764482) | 2764482..2765204 | - | 723 | WP_000182066.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
| MOP55_RS13525 (2765889) | 2765889..2766284 | + | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| MOP55_RS13530 (2766613) | 2766613..2767089 | + | 477 | WP_000030944.1 | hypothetical protein | - |
| MOP55_RS13535 (2767199) | 2767199..2767393 | + | 195 | WP_023134800.1 | hypothetical protein | - |
| MOP55_RS13540 (2767756) | 2767756..2768538 | + | 783 | WP_001747695.1 | DUF2971 domain-containing protein | - |
| MOP55_RS13545 (2768592) | 2768592..2768807 | - | 216 | WP_001747696.1 | hypothetical protein | - |
| MOP55_RS13550 (2768837) | 2768837..2769136 | - | 300 | WP_000775225.1 | hypothetical protein | - |
| MOP55_RS13555 (2769315) | 2769315..2769626 | + | 312 | WP_000558158.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MOP55_RS13560 (2769623) | 2769623..2770042 | + | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| MOP55_RS13565 (2770298) | 2770298..2770792 | + | 495 | WP_016419152.1 | glycosyltransferase | - |
| MOP55_RS25510 (2770789) | 2770789..2770947 | + | 159 | WP_023165344.1 | lipopolysaccharide 1,2-N-acetylglucosaminetransferase | - |
| MOP55_RS13570 (2771183) | 2771183..2771602 | - | 420 | WP_000354404.1 | GNAT family N-acetyltransferase | - |
| MOP55_RS13575 (2771973) | 2771973..2772242 | + | 270 | WP_077905753.1 | hypothetical protein | - |
| MOP55_RS13580 (2772408) | 2772408..2772548 | + | 141 | WP_000489598.1 | hypothetical protein | - |
| MOP55_RS13585 (2772694) | 2772694..2773236 | - | 543 | Protein_2668 | IS256 family transposase | - |
| MOP55_RS13590 (2773256) | 2773256..2773348 | - | 93 | WP_231923105.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2772694..2773371 | 677 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12398.19 Da Isoelectric Point: 10.0279
>T238540 WP_000558158.1 NZ_CP093407:2769315-2769626 [Salmonella enterica subsp. enterica serovar Agona]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T238540 NZ_LR890384:c4673527-4673243 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT238540 WP_000561389.1 NZ_CP093407:2769623-2770042 [Salmonella enterica subsp. enterica serovar Agona]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT238540 NZ_LR890384:c4673759-4673517 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|