Detailed information of TA system TA238533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4732601..4733203
• Replicon: chromosome
• Accession: NZ_CP093405
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: MOP56_RS23140
• Protein ID: WP_001159632.1
• Coordinates: 4732892..4733203 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOP56_RS23135
• Protein ID: WP_000362051.1
• Coordinates: 4732601..4732891 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP56_RS23120 (4730094)	4730094..4730996	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOP56_RS23125 (4730993)	4730993..4731628	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOP56_RS23130 (4731625)	4731625..4732554	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MOP56_RS23135 (4732601)	4732601..4732891	-	291	WP_000362051.1	NadS family protein	Antitoxin
MOP56_RS23140 (4732892)	4732892..4733203	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
MOP56_RS23145 (4733421)	4733421..4734350	+	930	WP_001127697.1	alpha/beta hydrolase	-
MOP56_RS23150 (4734436)	4734436..4734747	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOP56_RS23155 (4734744)	4734744..4735190	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MOP56_RS23160 (4735205)	4735205..4736146	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MOP56_RS23165 (4736191)	4736191..4736628	-	438	WP_000560973.1	D-aminoacyl-tRNA deacylase	-
MOP56_RS23170 (4736625)	4736625..4737497	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOP56_RS23175 (4737491)	4737491..4738090	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T238533 WP_001159632.1 NZ_CP093405:c4733203-4732892 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T238533 NZ_LR890384:348770-349117 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10957.57 Da
• Isoelectric Point: 10.6525

>AT238533 WP_000362051.1 NZ_CP093405:c4732891-4732601 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT238533 NZ_LR890384:349117-349416 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31