Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
| Location | 4683214..4683816 | Replicon | chromosome |
| Accession | NZ_CP093403 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.1436 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V7IUJ1 |
| Locus tag | MOP57_RS22795 | Protein ID | WP_001159632.1 |
| Coordinates | 4683505..4683816 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MOP57_RS22790 | Protein ID | WP_000362051.1 |
| Coordinates | 4683214..4683504 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOP57_RS22775 (4680707) | 4680707..4681609 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| MOP57_RS22780 (4681606) | 4681606..4682241 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| MOP57_RS22785 (4682238) | 4682238..4683167 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| MOP57_RS22790 (4683214) | 4683214..4683504 | - | 291 | WP_000362051.1 | NadS family protein | Antitoxin |
| MOP57_RS22795 (4683505) | 4683505..4683816 | - | 312 | WP_001159632.1 | cytotoxic translational repressor of toxin-antitoxin stability system | Toxin |
| MOP57_RS22800 (4684034) | 4684034..4684963 | + | 930 | WP_001127697.1 | alpha/beta hydrolase | - |
| MOP57_RS22805 (4685049) | 4685049..4685360 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | - |
| MOP57_RS22810 (4685357) | 4685357..4685803 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | - |
| MOP57_RS22815 (4685818) | 4685818..4686759 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| MOP57_RS22820 (4686804) | 4686804..4687241 | - | 438 | WP_000560973.1 | D-aminoacyl-tRNA deacylase | - |
| MOP57_RS22825 (4687238) | 4687238..4688110 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| MOP57_RS22830 (4688104) | 4688104..4688703 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12342.27 Da Isoelectric Point: 9.4460
>T238511 WP_001159632.1 NZ_CP093403:c4683816-4683505 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW
Download Length: 312 bp
>T238511 NZ_LR890374:c4657383-4656850 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10957.57 Da Isoelectric Point: 10.6525
>AT238511 WP_000362051.1 NZ_CP093403:c4683504-4683214 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY
Download Length: 291 bp
>AT238511 NZ_LR890374:c4657660-4657394 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|