Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2769740..2770467 | Replicon | chromosome |
| Accession | NZ_CP093403 | ||
| Organism | Salmonella enterica subsp. enterica serovar Agona strain R21.1436 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V7IQW2 |
| Locus tag | MOP57_RS13555 | Protein ID | WP_000558158.1 |
| Coordinates | 2769740..2770051 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MOP57_RS13560 | Protein ID | WP_000561389.1 |
| Coordinates | 2770048..2770467 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOP57_RS13520 (2764907) | 2764907..2765629 | - | 723 | WP_000182066.1 | SPI-1 type III secretion system guanine nucleotide exchange factor SopE2 | - |
| MOP57_RS13525 (2766314) | 2766314..2766709 | + | 396 | WP_000422887.1 | DUF1398 domain-containing protein | - |
| MOP57_RS13530 (2767038) | 2767038..2767514 | + | 477 | WP_000030944.1 | hypothetical protein | - |
| MOP57_RS13535 (2767624) | 2767624..2767818 | + | 195 | WP_023134800.1 | hypothetical protein | - |
| MOP57_RS13540 (2768181) | 2768181..2768963 | + | 783 | WP_001747695.1 | DUF2971 domain-containing protein | - |
| MOP57_RS13545 (2769017) | 2769017..2769232 | - | 216 | WP_001747696.1 | hypothetical protein | - |
| MOP57_RS13550 (2769262) | 2769262..2769561 | - | 300 | WP_000775225.1 | hypothetical protein | - |
| MOP57_RS13555 (2769740) | 2769740..2770051 | + | 312 | WP_000558158.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| MOP57_RS13560 (2770048) | 2770048..2770467 | + | 420 | WP_000561389.1 | helix-turn-helix domain-containing protein | Antitoxin |
| MOP57_RS13565 (2770723) | 2770723..2771217 | + | 495 | WP_016419152.1 | glycosyltransferase | - |
| MOP57_RS24940 (2771214) | 2771214..2771372 | + | 159 | WP_023165344.1 | lipopolysaccharide 1,2-N-acetylglucosaminetransferase | - |
| MOP57_RS13570 (2771608) | 2771608..2772027 | - | 420 | WP_000354404.1 | GNAT family N-acetyltransferase | - |
| MOP57_RS13575 (2772398) | 2772398..2772667 | + | 270 | WP_077905753.1 | hypothetical protein | - |
| MOP57_RS13580 (2772833) | 2772833..2772973 | + | 141 | WP_000489598.1 | hypothetical protein | - |
| MOP57_RS13585 (2773119) | 2773119..2773661 | - | 543 | Protein_2667 | IS256 family transposase | - |
| MOP57_RS13590 (2773681) | 2773681..2773773 | - | 93 | WP_231923105.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2773119..2773796 | 677 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12398.19 Da Isoelectric Point: 10.0279
>T238495 WP_000558158.1 NZ_CP093403:2769740-2770051 [Salmonella enterica subsp. enterica serovar Agona]
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
MHVISKEPFDEAARRYPNDSLAIKALYRLVREKDFSSPAELRTVIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFINKRF
YVKHIATHAEYDKLTRYYRENKE
Download Length: 312 bp
>T238495 NZ_LR890369:c4802738-4802454 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15301.49 Da Isoelectric Point: 4.6286
>AT238495 WP_000561389.1 NZ_CP093403:2770048-2770467 [Salmonella enterica subsp. enterica serovar Agona]
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MIANTAKAIEATKALVAAVPFLGGSASEKDYRDALALVDYLIENDDENPLIDFLASKIAEYEDNSKQFAEFNKSVAEMPV
GVALLRTLIDQYKLSYSDLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
>AT238495 NZ_LR890369:c4802970-4802728 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|