Detailed information of TA system TA238489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4778014..4778616
• Replicon: chromosome
• Accession: NZ_CP093402
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)

• Gene name: higB
• Uniprot ID: V7IUJ1
• Locus tag: MOP58_RS23390
• Protein ID: WP_001159632.1
• Coordinates: 4778305..4778616 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOP58_RS23385
• Protein ID: WP_000362051.1
• Coordinates: 4778014..4778304 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP58_RS23370 (4775507)	4775507..4776409	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOP58_RS23375 (4776406)	4776406..4777041	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOP58_RS23380 (4777038)	4777038..4777967	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MOP58_RS23385 (4778014)	4778014..4778304	-	291	WP_000362051.1	NadS family protein	Antitoxin
MOP58_RS23390 (4778305)	4778305..4778616	-	312	WP_001159632.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
MOP58_RS23395 (4778834)	4778834..4779763	+	930	WP_001127697.1	alpha/beta hydrolase	-
MOP58_RS23400 (4779849)	4779849..4780160	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
MOP58_RS23405 (4780157)	4780157..4780603	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
MOP58_RS23410 (4780618)	4780618..4781559	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MOP58_RS23415 (4781604)	4781604..4782041	-	438	WP_000560973.1	D-aminoacyl-tRNA deacylase	-
MOP58_RS23420 (4782038)	4782038..4782910	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOP58_RS23425 (4782904)	4782904..4783503	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12342.27 Da
• Isoelectric Point: 9.4460

>T238489 WP_001159632.1 NZ_CP093402:c4778616-4778305 [Salmonella enterica subsp. enterica serovar Agona]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T238489 NZ_LR890369:738293-738775 [Klebsiella pneumoniae]
ATGGAAATAAATGTCACTGCGCCTGCTTTACTGACAGAGGAGCATGTTCTTCATTCGTTCGATTGCGGGAATGCGGTACT
TGATGACTGGCTTCGCCGGCGTGCGTTGAAGAATCAGCATCTTAATGCTTCCCGGACATTCGTCATCTGTCCTGAAGGTA
CTGCGTGTGTAGTGGGTTATTATTCCCTTGCGACGGGCTCAGTTAGTCATGTCGACTTGAGTCGTAGTCTGCGACAGAAT
ATGCCCGATCCCGTACCGGTTGTTTTGCTGGGCCGCCTTGCAGTCGATGTATCCACTCAGGGCAATAACTTCGGGAAATG
GTTGCTGAATGATGCTGTGATGCGCGTATCGAATCTGGCGGATCAGGTCGGCATCAAGGCTATCATGGTGCATGCAATTG
ATGAGCGGGCTAAAGCGTTCTATGAATACTTTGGTTTTGTGCAGTCACCGGTTGCGGCTAACACGCTTTTCTACAAAATA
TAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10957.57 Da
• Isoelectric Point: 10.6525

>AT238489 WP_000362051.1 NZ_CP093402:c4778304-4778014 [Salmonella enterica subsp. enterica serovar Agona]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKVKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT238489 NZ_LR890369:738018-738302 [Klebsiella pneumoniae]
ATGCAAACTCCAGTCCGTAAATCCGTCCGTGACAAGCAAATCAATATCCGCGCCACGGATGAAGAACGTGCGGTGATTGA
TTACGCTGCGAGTCTGGTTAATAAAAACCGTACTGATTTCATCATTGAAAGGGCTGTGCATGAGGCCCAGAACATCATTC
TGGACCAGCGTGTGTTCGTTCTTGATGATGCCCGTTACCAGGCGTTCATCAGGCAGCTTGAAGCCCCTGTGCAGAATGTT
GAAGGTCGTCAGCGACTGATGGATGTAAAACCTGAATGGAAATAA

Structures

Toxin

• AlphaFold DB: A0A4U7VQ31