Detailed information of TA system TA238447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1603866..1604130
• Replicon: chromosome
• Accession: NZ_CP093400
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: MOP59_RS07725
• Protein ID: WP_001387489.1
• Coordinates: 1603978..1604130 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	1603866..1603926 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP59_RS07710 (1599968)	1599968..1601038	-	1071	WP_000151583.1	IncI1-type conjugal transfer protein TrbB	-
MOP59_RS07715 (1601057)	1601057..1602265	-	1209	WP_001383960.1	IncI1-type conjugal transfer protein TrbA	-
MOP59_RS07720 (1602572)	1602572..1603351	-	780	WP_275450201.1	protein FinQ	-
- (1603866)	1603866..1603926	-	61	NuclAT_1	-	Antitoxin
- (1603866)	1603866..1603926	-	61	NuclAT_1	-	Antitoxin
- (1603866)	1603866..1603926	-	61	NuclAT_1	-	Antitoxin
- (1603866)	1603866..1603926	-	61	NuclAT_1	-	Antitoxin
MOP59_RS07725 (1603978)	1603978..1604130	+	153	WP_001387489.1	Hok/Gef family protein	Toxin
MOP59_RS07730 (1604202)	1604202..1604453	-	252	WP_001291964.1	hypothetical protein	-
MOP59_RS24590 (1604954)	1604954..1605049	+	96	WP_000609148.1	DinQ-like type I toxin DqlB	-
MOP59_RS07740 (1605114)	1605114..1605290	-	177	WP_001054897.1	hypothetical protein	-
MOP59_RS07745 (1605682)	1605682..1605891	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
MOP59_RS07750 (1605963)	1605963..1606625	-	663	WP_000644796.1	plasmid IncI1-type surface exclusion protein ExcA	-
MOP59_RS07755 (1606696)	1606696..1608864	-	2169	WP_058649949.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaCTX-M-65	-	1541294..1642855	101561

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T238447 WP_001387489.1 NZ_CP093400:1603978-1604130 [Salmonella enterica subsp. enterica serovar Infantis]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T238447 NZ_LR890349:935586-935993 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT238447 NZ_CP093400:c1603926-1603866 [Salmonella enterica subsp. enterica serovar Infantis]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin