Detailed information of TA system TA238435

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4512648..4513402
• Replicon: chromosome
• Accession: NZ_CP093392
• Organism: Salmonella enterica strain P201982

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: MOV21_RS22170
• Protein ID: WP_000558166.1
• Coordinates: 4512648..4512959 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOV21_RS22175
• Protein ID: WP_001259011.1
• Coordinates: 4512956..4513402 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV21_RS22140 (4508314)	4508314..4509216	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOV21_RS22145 (4509213)	4509213..4509848	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOV21_RS22150 (4509845)	4509845..4510774	+	930	WP_242101006.1	formate dehydrogenase accessory protein FdhE	-
MOV21_RS22155 (4510812)	4510812..4511186	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
MOV21_RS22160 (4511186)	4511186..4511428	-	243	WP_001523745.1	CopG family transcriptional regulator	-
MOV21_RS22165 (4511633)	4511633..4512562	+	930	WP_058661473.1	alpha/beta hydrolase	-
MOV21_RS22170 (4512648)	4512648..4512959	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
MOV21_RS22175 (4512956)	4512956..4513402	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
MOV21_RS22180 (4513417)	4513417..4514358	-	942	WP_238727967.1	fatty acid biosynthesis protein FabY	-
MOV21_RS22185 (4514403)	4514403..4514840	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
MOV21_RS22190 (4514837)	4514837..4515709	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOV21_RS22195 (4515703)	4515703..4516302	-	600	WP_000965695.1	glucose-1-phosphatase	-
MOV21_RS22200 (4516493)	4516493..4517296	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
MOV21_RS22205 (4517330)	4517330..4518226	-	897	WP_001637558.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T238435 WP_000558166.1 NZ_CP093392:4512648-4512959 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T238435 NZ_LR890343:c3430603-3430319 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT238435 WP_001259011.1 NZ_CP093392:4512956-4513402 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT238435 NZ_LR890343:c3430835-3430593 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90