Detailed information of TA system TA238393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4521773..4522527
• Replicon: chromosome
• Accession: NZ_CP093390
• Organism: Salmonella enterica strain P289597

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: MOV19_RS22155
• Protein ID: WP_000558166.1
• Coordinates: 4521773..4522084 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOV19_RS22160
• Protein ID: WP_001259011.1
• Coordinates: 4522081..4522527 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV19_RS22125 (4517439)	4517439..4518341	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOV19_RS22130 (4518338)	4518338..4518973	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOV19_RS22135 (4518970)	4518970..4519899	+	930	WP_000027734.1	formate dehydrogenase accessory protein FdhE	-
MOV19_RS22140 (4519937)	4519937..4520311	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
MOV19_RS22145 (4520311)	4520311..4520553	-	243	WP_001523745.1	CopG family transcriptional regulator	-
MOV19_RS22150 (4520758)	4520758..4521687	+	930	WP_058661473.1	alpha/beta hydrolase	-
MOV19_RS22155 (4521773)	4521773..4522084	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
MOV19_RS22160 (4522081)	4522081..4522527	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
MOV19_RS22165 (4522542)	4522542..4523483	-	942	WP_238727967.1	fatty acid biosynthesis protein FabY	-
MOV19_RS22170 (4523528)	4523528..4523965	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
MOV19_RS22175 (4523962)	4523962..4524834	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOV19_RS22180 (4524828)	4524828..4525427	-	600	WP_000965695.1	glucose-1-phosphatase	-
MOV19_RS22185 (4525618)	4525618..4526421	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
MOV19_RS22190 (4526455)	4526455..4527351	-	897	WP_001637558.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T238393 WP_000558166.1 NZ_CP093390:4521773-4522084 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T238393 NZ_LR890327:c38889-38614 [Escherichia coli]
GTGTTTAGTCACCGCATTGTGGTCTCGGCCATTACTTACTCTGAAATGCGCTTCGGTGCCTCCGGTCCGAAGGCCTCCCC
GCGTCACGTGCAACTGGTTGATAAATTCTGCCCGTGCCTCGATGCCATCCTGTCTTGGGACCGCGCCGCGGTGGACGGCA
CCACGGATATTAAAGTGGCACTGCGCCAGGCCGGGACGCCGATCGGCCAGAACGATACGGCGATTGCCGGGCCTGAAGCT
GGAAGACTGGGTAAATTAACATCGCCCACACTCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT238393 WP_001259011.1 NZ_CP093390:4522081-4522527 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT238393 NZ_LR890327:c39208-38978 [Escherichia coli]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATCCATCTGCCCCGCGATTTGGATTTTGAGCGGGTGAG
AGAGCTGGAGATCGTCCGCGAAGGAGACAGCATCATCCTGCGTCCCGTCCAGCCGAACTGGGGCTCATTCGCGCAGCTCG
AAAAAGCCGATCCGGATTTTATGGCGGAGCGCGAGAATGTTGTCAGCGACGAAGGTCGATTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90