Detailed information of TA system TA238386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2120564..2121126
• Replicon: chromosome
• Accession: NZ_CP093390
• Organism: Salmonella enterica strain P289597

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A5U2RHV4
• Locus tag: MOV19_RS10640
• Protein ID: WP_071686223.1
• Coordinates: 2120848..2121126 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOV19_RS10635
• Protein ID: WP_001240607.1
• Coordinates: 2120564..2120848 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV19_RS10600 (2115740)	2115740..2115890	+	151	Protein_2080	hypothetical protein	-
MOV19_RS10605 (2115876)	2115876..2115977	+	102	Protein_2081	tail fiber assembly protein	-
MOV19_RS10610 (2116178)	2116178..2116900	-	723	WP_079787802.1	SPI-1 type III secretion system guanine nucleotide exchange factor SopE	-
MOV19_RS10615 (2117114)	2117114..2117332	+	219	Protein_2083	helix-turn-helix domain-containing protein	-
MOV19_RS10620 (2117464)	2117464..2118165	-	702	WP_242166642.1	T3SS effector NleG family protein	-
MOV19_RS10625 (2119029)	2119029..2119424	-	396	Protein_2085	tyrosine-type recombinase/integrase	-
MOV19_RS10630 (2120067)	2120067..2120405	+	339	WP_114050305.1	T3SS effector NleG family protein	-
MOV19_RS10635 (2120564)	2120564..2120848	-	285	WP_001240607.1	HigA family addiction module antitoxin	Antitoxin
MOV19_RS10640 (2120848)	2120848..2121126	-	279	WP_071686223.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MOV19_RS10645 (2121378)	2121378..2121638	+	261	WP_002953402.1	hypothetical protein	-
MOV19_RS10650 (2121709)	2121709..2122392	-	684	WP_238728147.1	PipA/GogA/GtgA family type III secretion system effector	-
MOV19_RS10655 (2122911)	2122911..2123369	+	459	WP_000502123.1	IS200/IS605-like element IS200F family transposase	-
MOV19_RS10660 (2123529)	2123529..2124359	+	831	WP_227012499.1	hypothetical protein	-
MOV19_RS10665 (2124362)	2124362..2124893	+	532	Protein_2093	tail fiber assembly protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	sopE2 / sspH2 / sspH1 / sspH2 / sopE2 / sopE2	2104390..2146857	42467
	-	flank	IS/Tn	-	-	2123124..2123369	245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10751.24 Da
• Isoelectric Point: 9.4011

>T238386 WP_071686223.1 NZ_CP093390:c2121126-2120848 [Salmonella enterica]
MIKSFRHKGLKKFYQKGDSSGLEQSLVPRLKNRLSMLDAAKTIDFLNQQGYDLHELKGDRAETWSIKVSGNWRLTFIFEN
GDVYVLNLEDYH

Nucleotide

• Length: 279 bp

>T238386 NZ_LR890326:c4615603-4615316 [Escherichia coli]
ATAAGGACATGCCATGAGAACCCTGGTACAGGCTTTACGGAAGAAACAAAAAATACATTGGATCAAATATTTAAATCTCC
TGTTCCTCAAGGGATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTT
CGCGTTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCT
GTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10187.74 Da
• Isoelectric Point: 5.6051

>AT238386 WP_001240607.1 NZ_CP093390:c2120848-2120564 [Salmonella enterica]
MAMFDPAYPGEIIAEILEDQGVSLRQFAVAMNIAPSTASRILSGKVSITPEMAVKLAIVLGGDAESWLNLQNNYSLSQAR
KTVDITHVHRLSFA

Nucleotide

• Length: 285 bp

>AT238386 NZ_LR890326:c4615319-4614960 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A0A5U2RHV4