Detailed information of TA system TA238371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4660978..4661732
• Replicon: chromosome
• Accession: NZ_CP093386
• Organism: Salmonella enterica strain P048595

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: MOQ57_RS22620
• Protein ID: WP_000558166.1
• Coordinates: 4660978..4661289 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOQ57_RS22625
• Protein ID: WP_001259011.1
• Coordinates: 4661286..4661732 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOQ57_RS22590 (4656636)	4656636..4657538	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
MOQ57_RS22595 (4657535)	4657535..4658170	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOQ57_RS22600 (4658167)	4658167..4659096	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
MOQ57_RS22605 (4659143)	4659143..4659433	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
MOQ57_RS22610 (4659434)	4659434..4659745	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
MOQ57_RS22615 (4659963)	4659963..4660892	+	930	WP_001127703.1	alpha/beta hydrolase	-
MOQ57_RS22620 (4660978)	4660978..4661289	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
MOQ57_RS22625 (4661286)	4661286..4661732	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
MOQ57_RS22630 (4661747)	4661747..4662688	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
MOQ57_RS22635 (4662733)	4662733..4663170	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
MOQ57_RS22640 (4663167)	4663167..4664039	-	873	WP_000921427.1	virulence factor BrkB family protein	-
MOQ57_RS22645 (4664033)	4664033..4664632	-	600	WP_000965695.1	glucose-1-phosphatase	-
MOQ57_RS22650 (4664823)	4664823..4665626	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
MOQ57_RS22655 (4665660)	4665660..4666556	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T238371 WP_000558166.1 NZ_CP093386:4660978-4661289 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T238371 NZ_LR890326:439406-439696 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACTGGGATATCGCCTGGTCTATTCCGTCAATGATAAAGAGTTACTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAAAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT238371 WP_001259011.1 NZ_CP093386:4661286-4661732 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT238371 NZ_LR890326:439174-439416 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATTACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90