Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4659143..4659745 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag MOQ57_RS22610 Protein ID WP_001159630.1
Coordinates 4659434..4659745 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MOQ57_RS22605 Protein ID WP_000362050.1
Coordinates 4659143..4659433 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS22590 (4656636) 4656636..4657538 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
MOQ57_RS22595 (4657535) 4657535..4658170 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
MOQ57_RS22600 (4658167) 4658167..4659096 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
MOQ57_RS22605 (4659143) 4659143..4659433 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
MOQ57_RS22610 (4659434) 4659434..4659745 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
MOQ57_RS22615 (4659963) 4659963..4660892 + 930 WP_001127703.1 alpha/beta hydrolase -
MOQ57_RS22620 (4660978) 4660978..4661289 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
MOQ57_RS22625 (4661286) 4661286..4661732 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
MOQ57_RS22630 (4661747) 4661747..4662688 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
MOQ57_RS22635 (4662733) 4662733..4663170 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
MOQ57_RS22640 (4663167) 4663167..4664039 - 873 WP_000921427.1 virulence factor BrkB family protein -
MOQ57_RS22645 (4664033) 4664033..4664632 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(36-85)


Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T238370 WP_001159630.1 NZ_CP093386:c4659745-4659434 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T238370 NZ_LR890326:428002-428352 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT238370 WP_000362050.1 NZ_CP093386:c4659433-4659143 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT238370 NZ_LR890326:427757-428008 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64


Antitoxin

Source ID Structure

References