238362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2459242..2459764 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MOQ57_RS12035 Protein ID WP_000221343.1
Coordinates 2459480..2459764 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MOQ57_RS12030 Protein ID WP_000885424.1
Coordinates 2459242..2459490 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS12005 (2454531) 2454531..2455924 + 1394 Protein_2356 hypothetical protein -
MOQ57_RS12010 (2456732) 2456732..2457446 + 715 Protein_2357 helix-turn-helix domain-containing protein -
MOQ57_RS12015 (2457502) 2457502..2458410 - 909 WP_077918335.1 hypothetical protein -
MOQ57_RS12020 (2458553) 2458553..2458885 - 333 WP_000253154.1 DUF1493 family protein -
MOQ57_RS12025 (2458875) 2458875..2459090 - 216 WP_000206207.1 hypothetical protein -
MOQ57_RS12030 (2459242) 2459242..2459490 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MOQ57_RS12035 (2459480) 2459480..2459764 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOQ57_RS12040 (2459935) 2459935..2460324 + 390 WP_000194089.1 RidA family protein -
MOQ57_RS12045 (2460376) 2460376..2461455 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MOQ57_RS12050 (2461648) 2461648..2462136 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
MOQ57_RS12055 (2462181) 2462181..2463689 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2454534..2466546 12012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T238362 WP_000221343.1 NZ_CP093386:2459480-2459764 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T238362 NZ_LR890323:c4507634-4507101 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT238362 WP_000885424.1 NZ_CP093386:2459242-2459490 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT238362 NZ_LR890323:c4507911-4507645 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References