Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4688440..4689194 Replicon chromosome
Accession NZ_CP093373
Organism Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag MNU28_RS22735 Protein ID WP_000558166.1
Coordinates 4688883..4689194 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MNU28_RS22730 Protein ID WP_001259011.1
Coordinates 4688440..4688886 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNU28_RS22700 (4683616) 4683616..4684512 + 897 WP_165717276.1 sugar kinase -
MNU28_RS22705 (4684546) 4684546..4685349 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
MNU28_RS22710 (4685540) 4685540..4686139 + 600 WP_000965698.1 glucose-1-phosphatase -
MNU28_RS22715 (4686133) 4686133..4687005 + 873 WP_000921423.1 virulence factor BrkB family protein -
MNU28_RS22720 (4687002) 4687002..4687439 + 438 WP_023993693.1 D-aminoacyl-tRNA deacylase -
MNU28_RS22725 (4687484) 4687484..4688425 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
MNU28_RS22730 (4688440) 4688440..4688886 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
MNU28_RS22735 (4688883) 4688883..4689194 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
MNU28_RS22740 (4689280) 4689280..4690209 - 930 WP_021294279.1 alpha/beta hydrolase -
MNU28_RS22745 (4690427) 4690427..4690738 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
MNU28_RS22750 (4690739) 4690739..4691029 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
MNU28_RS22755 (4691076) 4691076..4692005 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
MNU28_RS22760 (4692002) 4692002..4692637 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
MNU28_RS22765 (4692634) 4692634..4693536 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T238317 WP_000558166.1 NZ_CP093373:c4689194-4688883 [Salmonella enterica subsp. enterica serovar Infantis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T238317 NZ_LR890301:69663-69812 [Escherichia coli]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT238317 WP_001259011.1 NZ_CP093373:c4688886-4688440 [Salmonella enterica subsp. enterica serovar Infantis]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT238317 NZ_LR890301:c69618-69559 [Escherichia coli]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References