Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 3623838..3624492 Replicon chromosome
Accession NZ_CP093333
Organism Pseudomonas simiae strain H4-B59

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MNO08_RS16530 Protein ID WP_042572419.1
Coordinates 3623838..3624188 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C3JY95
Locus tag MNO08_RS16535 Protein ID WP_010209571.1
Coordinates 3624178..3624492 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO08_RS16520 (MNO08_16520) 3620597..3622129 + 1533 WP_010209575.1 NADH-quinone oxidoreductase subunit M -
MNO08_RS16525 (MNO08_16525) 3622137..3623600 + 1464 WP_012724956.1 NADH-quinone oxidoreductase subunit NuoN -
MNO08_RS16530 (MNO08_16530) 3623838..3624188 + 351 WP_042572419.1 toxin Toxin
MNO08_RS16535 (MNO08_16535) 3624178..3624492 + 315 WP_010209571.1 XRE family transcriptional regulator Antitoxin
MNO08_RS16540 (MNO08_16540) 3624554..3625306 - 753 WP_010209570.1 outer membrane beta-barrel protein -
MNO08_RS16545 (MNO08_16545) 3625440..3626267 - 828 WP_042572142.1 arylamine N-acetyltransferase -
MNO08_RS16550 (MNO08_16550) 3626388..3626624 + 237 WP_010209566.1 hypothetical protein -
MNO08_RS16555 (MNO08_16555) 3626656..3626856 - 201 WP_010209565.1 DUF6021 family protein -
MNO08_RS16560 (MNO08_16560) 3626871..3627047 - 177 WP_010209563.1 hypothetical protein -
MNO08_RS16565 (MNO08_16565) 3627161..3627682 + 522 WP_241912506.1 DUF3087 family protein -
MNO08_RS16570 (MNO08_16570) 3627724..3628854 - 1131 WP_021492768.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13730.57 Da        Isoelectric Point: 8.5175

>T238177 WP_042572419.1 NZ_CP093333:3623838-3624188 [Pseudomonas simiae]
MDALFIELPAFERHRKDYLSDELFHGFQQALMKNPEAGDVIEGTGGLRKVSFVDERRNKGKRGGLRVIYYWWSDGTQFWL
FTLYGKHEQDDLTPQHKKALKHMLDREIKARTHHET

Download         Length: 351 bp

>T238177 NZ_LR890254:c1536690-1536588 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11741.51 Da        Isoelectric Point: 10.4449

>AT238177 WP_010209571.1 NZ_CP093333:3624178-3624492 [Pseudomonas simiae]
MKREIFSELVEGFDALANERQGKVTLRTHKVHLNNLEPLTAEEVVAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRAKPN
AQAATLIRLVARFPETVAQLAALG

Download         Length: 315 bp

>AT238177 NZ_LR890254:1536581-1536726 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N5F9B6

References