Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 2655107..2656461 | Replicon | chromosome |
| Accession | NZ_CP093332 | ||
| Organism | Buttiauxella ferragutiae strain H4-C11 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | MNO13_RS12285 | Protein ID | WP_241938787.1 |
| Coordinates | 2655107..2656144 (-) | Length | 346 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | A0A3G2I9X5 |
| Locus tag | MNO13_RS12290 | Protein ID | WP_064546608.1 |
| Coordinates | 2656147..2656461 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNO13_RS12250 (MNO13_12250) | 2650537..2650725 | - | 189 | WP_064546594.1 | YegP family protein | - |
| MNO13_RS12255 (MNO13_12255) | 2650892..2651065 | + | 174 | WP_064546596.1 | GhoT/OrtT family toxin | - |
| MNO13_RS12260 (MNO13_12260) | 2651106..2651423 | + | 318 | WP_064546598.1 | N(4)-acetylcytidine aminohydrolase | - |
| MNO13_RS12265 (MNO13_12265) | 2651464..2651679 | - | 216 | WP_064546600.1 | YdcH family protein | - |
| MNO13_RS12270 (MNO13_12270) | 2651950..2652711 | + | 762 | WP_232885839.1 | siderophore-interacting protein | - |
| MNO13_RS12275 (MNO13_12275) | 2652722..2653306 | + | 585 | WP_083963375.1 | PadR family transcriptional regulator | - |
| MNO13_RS12280 (MNO13_12280) | 2653393..2655057 | + | 1665 | WP_241938786.1 | methyl-accepting chemotaxis protein | - |
| MNO13_RS12285 (MNO13_12285) | 2655107..2656144 | - | 1038 | WP_241938787.1 | HipA domain-containing protein | Toxin |
| MNO13_RS12290 (MNO13_12290) | 2656147..2656461 | - | 315 | WP_064546608.1 | HipA N-terminal domain-containing protein | Antitoxin |
| MNO13_RS12295 (MNO13_12295) | 2656446..2656769 | - | 324 | WP_241938788.1 | helix-turn-helix domain-containing protein | - |
| MNO13_RS12300 (MNO13_12300) | 2657083..2658111 | + | 1029 | WP_241938789.1 | MsnO8 family LLM class oxidoreductase | - |
| MNO13_RS12305 (MNO13_12305) | 2658122..2659243 | + | 1122 | WP_064546614.1 | amidohydrolase | - |
| MNO13_RS12310 (MNO13_12310) | 2659307..2660608 | + | 1302 | Protein_2414 | LLM class flavin-dependent oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 346 a.a. Molecular weight: 38880.55 Da Isoelectric Point: 6.4312
>T238171 WP_241938787.1 NZ_CP093332:c2656144-2655107 [Buttiauxella ferragutiae]
MRCHILLTPLLQAKEQESGYSSKGLKQLTGSGKVNPQLSFTRDDFIHELPKAQRGMSISGYQPKLQMVVRAGEFAVVEHQ
GEYILKPSPAEFPHLAENEHATMTLMARLGFDVPPHGLVSFAAVDNEAERELAFVIRRFDRDIQTGAAIHQEQLDAAMNV
GEKYGKTGSDGKQYVSYQQLAEFLTQHVNSNIAFKIDLFRRIAYAYLLGNNDMHLRNFGLIHPRIGEPTLSPVYDFVSVA
PYPAIFSSGFMALPLLRCEEGDRELAPGFKTAYGEYLGMDFQALGLSMGMTEKLIVKLLNDIRKESRIVDAVYRDSFMPA
KDVEATLRCYHQRLDRLMRLDEAEL
MRCHILLTPLLQAKEQESGYSSKGLKQLTGSGKVNPQLSFTRDDFIHELPKAQRGMSISGYQPKLQMVVRAGEFAVVEHQ
GEYILKPSPAEFPHLAENEHATMTLMARLGFDVPPHGLVSFAAVDNEAERELAFVIRRFDRDIQTGAAIHQEQLDAAMNV
GEKYGKTGSDGKQYVSYQQLAEFLTQHVNSNIAFKIDLFRRIAYAYLLGNNDMHLRNFGLIHPRIGEPTLSPVYDFVSVA
PYPAIFSSGFMALPLLRCEEGDRELAPGFKTAYGEYLGMDFQALGLSMGMTEKLIVKLLNDIRKESRIVDAVYRDSFMPA
KDVEATLRCYHQRLDRLMRLDEAEL
Download Length: 1038 bp
>T238171 NZ_LR890245:c4634130-4633597 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12014.68 Da Isoelectric Point: 6.2228
>AT238171 WP_064546608.1 NZ_CP093332:c2656461-2656147 [Buttiauxella ferragutiae]
MRRRVEVWLYGEPVGELRQHDDGFEFSYRADYIGPPLSLSLPVRVGHFRSQTLPPFFASLAPEGWLKKRYSQLQQRDEHD
LLGMLIDNGKNLIGAVQLVSMQED
MRRRVEVWLYGEPVGELRQHDDGFEFSYRADYIGPPLSLSLPVRVGHFRSQTLPPFFASLAPEGWLKKRYSQLQQRDEHD
LLGMLIDNGKNLIGAVQLVSMQED
Download Length: 315 bp
>AT238171 NZ_LR890245:c4634407-4634141 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|