Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 3523805..3524632 Replicon chromosome
Accession NZ_CP093328
Organism Rahnella aceris strain S2-A69

Toxin (Protein)


Gene name yhaV Uniprot ID H8NM45
Locus tag MNO10_RS16260 Protein ID WP_014411451.1
Coordinates 3524156..3524632 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0H3F4N7
Locus tag MNO10_RS16255 Protein ID WP_013573435.1
Coordinates 3523805..3524149 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO10_RS16230 (MNO10_16230) 3519446..3520381 + 936 WP_112197519.1 ABC transporter permease -
MNO10_RS16235 (MNO10_16235) 3520374..3521240 + 867 WP_014411456.1 ABC transporter ATP-binding protein -
MNO10_RS16240 (MNO10_16240) 3521240..3522022 + 783 WP_014411455.1 ABC transporter ATP-binding protein -
MNO10_RS16245 (MNO10_16245) 3522042..3523421 + 1380 WP_166861272.1 MmgE/PrpD family protein -
MNO10_RS16250 (MNO10_16250) 3523568..3523723 + 156 WP_232829653.1 type II toxin-antitoxin system RelE/ParE family toxin -
MNO10_RS16255 (MNO10_16255) 3523805..3524149 + 345 WP_013573435.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
MNO10_RS16260 (MNO10_16260) 3524156..3524632 + 477 WP_014411451.1 type II toxin-antitoxin system YhaV family toxin Toxin
MNO10_RS16270 (MNO10_16270) 3524911..3526590 - 1680 WP_131638498.1 kdo(2)-lipid A phosphoethanolamine 7''-transferase -
MNO10_RS16275 (MNO10_16275) 3526862..3527284 - 423 WP_013573432.1 organic hydroperoxide resistance protein -
MNO10_RS16280 (MNO10_16280) 3527419..3527877 - 459 WP_013573431.1 MarR family transcriptional regulator -
MNO10_RS16285 (MNO10_16285) 3527948..3529393 - 1446 WP_112151980.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(13-148)

Antitoxin

SpoVT-AbrB domain

(15-53)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18482.31 Da        Isoelectric Point: 9.9550

>T238154 WP_014411451.1 NZ_CP093328:3524156-3524632 [Rahnella aceris]
MHNQAMEINGWTLLAHPLILQQIQALTDQVVLLRRKDPAGYKSKNATKRLAAINKLMFDVIPQDPARVEFRQGDTLGGEF
SHWFRAKFFQQYRLFFRYNLKSRIIIYAWVNDDKELRAYESKTDAYRMFRKMLKSGEPPDNWQALCEASGKVAAEELP

Download         Length: 477 bp

>T238154 NZ_LR890240:323051-323419 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12701.48 Da        Isoelectric Point: 4.3324

>AT238154 WP_013573435.1 NZ_CP093328:3523805-3524149 [Rahnella aceris]
MSASALWGIKFEAESKVTRRFQTTIPATIRKALNLTENDRIQYKILPDGQVVISRQLEEAEDPVISAFLGFVAKDMLNNP
ENMQPVTLSLHEKINVLTAGMAIDLESPLSDDDE

Download         Length: 345 bp

>AT238154 NZ_LR890240:322833-323054 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8NM45

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3F4N7

References