Detailed information of TA system TA238140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3871511..3872016
• Replicon: chromosome
• Accession: NZ_CP093326
• Organism: Arthrobacter sulfonylureivorans strain S4-C24

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MNQ99_RS17790
• Protein ID: WP_241913925.1
• Coordinates: 3871511..3871768 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MNQ99_RS17795
• Protein ID: WP_127514147.1
• Coordinates: 3871765..3872016 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNQ99_RS17765 (MNQ99_17765)	3866818..3867150	-	333	WP_241913920.1	metalloregulator ArsR/SmtB family transcription factor	-
MNQ99_RS17770 (MNQ99_17770)	3867304..3867714	-	411	WP_241913921.1	cupin domain-containing protein	-
MNQ99_RS17775 (MNQ99_17775)	3867794..3868816	-	1023	WP_241913922.1	zinc-dependent alcohol dehydrogenase family protein	-
MNQ99_RS17780 (MNQ99_17780)	3868941..3869837	+	897	WP_241913923.1	helix-turn-helix transcriptional regulator	-
MNQ99_RS17785 (MNQ99_17785)	3870005..3871480	+	1476	WP_241913924.1	amino acid permease	-
MNQ99_RS17790 (MNQ99_17790)	3871511..3871768	-	258	WP_241913925.1	Txe/YoeB family addiction module toxin	Toxin
MNQ99_RS17795 (MNQ99_17795)	3871765..3872016	-	252	WP_127514147.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MNQ99_RS17800 (MNQ99_17800)	3872142..3872846	+	705	WP_241915418.1	DsbA family oxidoreductase	-
MNQ99_RS17805 (MNQ99_17805)	3872922..3873557	-	636	WP_241915419.1	dihydrofolate reductase family protein	-
MNQ99_RS17810 (MNQ99_17810)	3874062..3875246	+	1185	WP_127514141.1	MFS transporter	-
MNQ99_RS17815 (MNQ99_17815)	3875267..3875938	-	672	WP_127514139.1	LytR C-terminal domain-containing protein	-
MNQ99_RS17820 (MNQ99_17820)	3875931..3876230	-	300	WP_127514137.1	type II toxin-antitoxin system VapB family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10396.77 Da
• Isoelectric Point: 8.0628

>T238140 WP_241913925.1 NZ_CP093326:c3871768-3871511 [Arthrobacter sulfonylureivorans]
MKLVWDEDAWADYEWWQLQDRKTLKRINNLIRDIARNGNEGIGKPEPLKHGFHGYWLRRISAEHRLVYRLEADEIRIASC
RYHYD

Nucleotide

• Length: 258 bp

>T238140 NZ_LR890231:55015-55497 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9390.50 Da
• Isoelectric Point: 4.7077

>AT238140 WP_127514147.1 NZ_CP093326:c3872016-3871765 [Arthrobacter sulfonylureivorans]
MRTMSYSESRAKYAETLNSVVDDREEVVITRAGHEPVVMVALEDYESLKESAYLLRNPANARRLLASIERLESGHGVEHE
LAE

Nucleotide

• Length: 252 bp

>AT238140 NZ_LR890231:54761-55027 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA