238121

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1118421..1119073 Replicon chromosome
Accession NZ_CP093323
Organism Serratia plymuthica strain B37/06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MNO11_RS05030 Protein ID WP_062868391.1
Coordinates 1118729..1119073 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2X4V2M0
Locus tag MNO11_RS05025 Protein ID WP_063200237.1
Coordinates 1118421..1118723 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNO11_RS05005 (MNO11_05005) 1113699..1114607 + 909 WP_004952315.1 LysR family transcriptional regulator -
MNO11_RS05010 (MNO11_05010) 1114924..1116078 + 1155 WP_004952311.1 MFS transporter -
MNO11_RS05015 (MNO11_05015) 1116068..1116991 - 924 WP_004952309.1 LysR family transcriptional regulator -
MNO11_RS05020 (MNO11_05020) 1117128..1118390 + 1263 WP_241921761.1 diaminopimelate decarboxylase -
MNO11_RS05025 (MNO11_05025) 1118421..1118723 - 303 WP_063200237.1 XRE family transcriptional regulator Antitoxin
MNO11_RS05030 (MNO11_05030) 1118729..1119073 - 345 WP_062868391.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNO11_RS05035 (MNO11_05035) 1119212..1120222 - 1011 WP_062868390.1 LacI family DNA-binding transcriptional regulator -
MNO11_RS05040 (MNO11_05040) 1120374..1120829 + 456 WP_197929812.1 GNAT family N-acetyltransferase -
MNO11_RS05045 (MNO11_05045) 1120826..1121845 - 1020 WP_004952299.1 HTH-type transcriptional regulator GalR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13304.36 Da        Isoelectric Point: 10.0970

>T238121 WP_062868391.1 NZ_CP093323:c1119073-1118729 [Serratia plymuthica]
MWQVVTVERFDDWFLSLNGDEQKSLLAGIFKLQEFGPLLARPHADTLHFSGSIKHLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRLLPIAAMEFSHYLATQR

Download         Length: 345 bp

>T238121 NZ_LR890217:3923394-3923612 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11126.05 Da        Isoelectric Point: 10.1425

>AT238121 WP_063200237.1 NZ_CP093323:c1118723-1118421 [Serratia plymuthica]
MAKPLSNLIDKLDPTVVAAARQKAEKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVELPNGQHRRMTL

Download         Length: 303 bp

>AT238121 NZ_LR890217:3922993-3923367 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4V2M0

References