Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1366435..1367104 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MNQ97_RS06245 Protein ID WP_050312674.1
Coordinates 1366435..1366782 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MNQ97_RS06250 Protein ID WP_241916198.1
Coordinates 1366787..1367104 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS06220 (MNQ97_06220) 1362009..1362425 - 417 WP_074000306.1 DUF2502 domain-containing protein -
MNQ97_RS06225 (MNQ97_06225) 1362583..1363572 - 990 WP_241916197.1 aldo/keto reductase -
MNQ97_RS06230 (MNQ97_06230) 1363699..1364583 - 885 WP_050084847.1 LysR family transcriptional regulator -
MNQ97_RS06235 (MNQ97_06235) 1364686..1365162 + 477 WP_050084848.1 multidrug/biocide efflux PACE transporter -
MNQ97_RS06240 (MNQ97_06240) 1365339..1366304 + 966 WP_050084849.1 glucokinase -
MNQ97_RS06245 (MNQ97_06245) 1366435..1366782 + 348 WP_050312674.1 toxin Toxin
MNQ97_RS06250 (MNQ97_06250) 1366787..1367104 + 318 WP_241916198.1 transcriptional regulator Antitoxin
MNQ97_RS06255 (MNQ97_06255) 1367130..1368374 - 1245 WP_241916199.1 OFA family MFS transporter -
MNQ97_RS06260 (MNQ97_06260) 1368598..1369338 - 741 WP_050133197.1 LytTR family DNA-binding domain-containing protein -
MNQ97_RS06265 (MNQ97_06265) 1369342..1371042 - 1701 WP_050312677.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-88)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13670.00 Da        Isoelectric Point: 9.9631

>T238106 WP_050312674.1 NZ_CP093322:1366435-1366782 [Yersinia intermedia]
MDAVFVELPSFERLRFEYLSDDEYRSLQIMLMNNPMIGDVIQQTGGLRKMRFSDPRRGKGKRGGVRVIYYWWVERLQFLL
FTLYSKGEITDLTETQRKILGDLLKCRKAELTLLR

Download         Length: 348 bp

>T238106 NZ_LR890209:3952963-3953181 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAAATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11952.65 Da        Isoelectric Point: 9.8814

>AT238106 WP_241916198.1 NZ_CP093322:1366787-1367104 [Yersinia intermedia]
MKKRDLFSELLEGMDAWQGANTGKKTLKTHKVSGESSVTLTADELRHIRETLNISQALFAHYLQAGTATYQNWEQGRAKP
NKQAILLIRMVQRDPHTLQTLAELY

Download         Length: 318 bp

>AT238106 NZ_LR890209:3952562-3952936 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References