Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 526659..527242 Replicon chromosome
Accession NZ_CP093322
Organism Yersinia intermedia strain N6/293

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MNQ97_RS02300 Protein ID WP_241916064.1
Coordinates 526964..527242 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MNQ97_RS02295 Protein ID WP_050312922.1
Coordinates 526659..526964 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNQ97_RS02280 (MNQ97_02280) 522640..523752 + 1113 WP_050087649.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MNQ97_RS02285 (MNQ97_02285) 523756..524496 + 741 WP_050134689.1 KDGP aldolase family protein -
MNQ97_RS02290 (MNQ97_02290) 524641..526569 + 1929 WP_074007461.1 PRD domain-containing protein -
MNQ97_RS02295 (MNQ97_02295) 526659..526964 - 306 WP_050312922.1 HigA family addiction module antitoxin Antitoxin
MNQ97_RS02300 (MNQ97_02300) 526964..527242 - 279 WP_241916064.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MNQ97_RS02305 (MNQ97_02305) 527323..530055 - 2733 WP_050087641.1 magnesium-translocating P-type ATPase -
MNQ97_RS02310 (MNQ97_02310) 530580..531527 + 948 WP_005188487.1 trehalose operon repressor TreR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10681.11 Da        Isoelectric Point: 6.8794

>T238102 WP_241916064.1 NZ_CP093322:c527242-526964 [Yersinia intermedia]
MIKSWKHKGLQRFVETGSAADINPLHVMRLRGRLRFIDLAETIEDVNVAGYKLHSLQGDREGIWSVTVSGNWRITFEFKD
GDAFILNYEDYH

Download         Length: 279 bp

>T238102 NZ_LR890209:361282-361629 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11024.81 Da        Isoelectric Point: 6.0661

>AT238102 WP_050312922.1 NZ_CP093322:c526964-526659 [Yersinia intermedia]
MKMHNPPHPGEMIEGILEDLDLGIRELARALNVAPSTVQRLVSCHSAVSPEMAVKLAAVLGSTPAMWLRLQAAYDLGKAE
ENIDISNLTKLYKPEPVSLHN

Download         Length: 306 bp

>AT238102 NZ_LR890209:361629-361928 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACGTTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References