Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1727355..1727857 | Replicon | chromosome |
| Accession | NZ_CP093317 | ||
| Organism | Escherichia coli strain HUM3355 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | MLA23_RS08135 | Protein ID | WP_000767829.1 |
| Coordinates | 1727603..1727857 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | MLA23_RS08130 | Protein ID | WP_001259255.1 |
| Coordinates | 1727355..1727606 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLA23_RS08105 (1722532) | 1722532..1723599 | - | 1068 | WP_000080090.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| MLA23_RS08110 (1723599) | 1723599..1724669 | - | 1071 | WP_000108933.1 | histidinol-phosphate transaminase | - |
| MLA23_RS08115 (1724666) | 1724666..1725970 | - | 1305 | WP_001446927.1 | histidinol dehydrogenase | - |
| MLA23_RS08120 (1725976) | 1725976..1726875 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| MLA23_RS08125 (1727021) | 1727021..1727071 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| MLA23_RS08130 (1727355) | 1727355..1727606 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| MLA23_RS08135 (1727603) | 1727603..1727857 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| MLA23_RS08140 (1727940) | 1727940..1728764 | + | 825 | WP_038989073.1 | SDR family oxidoreductase | - |
| MLA23_RS08145 (1728810) | 1728810..1729739 | + | 930 | WP_064221651.1 | LysR substrate-binding domain-containing protein | - |
| MLA23_RS08150 (1729954) | 1729954..1730016 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| MLA23_RS08155 (1730006) | 1730006..1731364 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| MLA23_RS08160 (1731544) | 1731544..1732602 | + | 1059 | WP_000492330.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| MLA23_RS08165 (1732616) | 1732616..1732843 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T238072 WP_000767829.1 NZ_CP093317:1727603-1727857 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T238072 NZ_LR890201:c13093-12743 [Escherichia coli]
ATGTGGACTGTTTATTTTGGCAGATTATTTGATGAATGGTTTGAAGAACAGGAACTAGCCCTAAAACGAAAAGTGCTGGC
TGAACTTAGACATCTTGAAAAGTTTGGCCCCTCTCTTTCACGACCACATGCAGATACTGTGAAAGGGTCACGTCATAAGA
ACATGAAGGAACTACGTATACAATATGAGGGACACCCAATCAGGGCATTCTTTGCATTTGATCCGATTAGGCAAGCAATC
ATTCTTTGCGCTGGCGACAAAAGTAATGATAAAAAATTTTATGACAGAATGATTCGTATTGCTGACGAAGAATTTTCCAC
TCACTTAGCCGAACTGGAGGGCAAAAAATGA
ATGTGGACTGTTTATTTTGGCAGATTATTTGATGAATGGTTTGAAGAACAGGAACTAGCCCTAAAACGAAAAGTGCTGGC
TGAACTTAGACATCTTGAAAAGTTTGGCCCCTCTCTTTCACGACCACATGCAGATACTGTGAAAGGGTCACGTCATAAGA
ACATGAAGGAACTACGTATACAATATGAGGGACACCCAATCAGGGCATTCTTTGCATTTGATCCGATTAGGCAAGCAATC
ATTCTTTGCGCTGGCGACAAAAGTAATGATAAAAAATTTTATGACAGAATGATTCGTATTGCTGACGAAGAATTTTCCAC
TCACTTAGCCGAACTGGAGGGCAAAAAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT238072 WP_001259255.1 NZ_CP093317:1727355-1727606 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT238072 NZ_LR890201:c12746-12447 [Escherichia coli]
ATGAGAACATTAGAAGAAGTAATTGCGGCTCAATCACCTGAAAGTCAGGCTATCATCAAAGCTATGGCTGATGAGATGAT
TCTGGAAACAGGACTGCAAATGATGCGTGAAGAATTGCAGCTTTCACAAAAACAGGTTGCTGATGCAATGGGAATCAGCC
AGCCCGCTGTAACTCAACTGGAACAGCGCGGAAATGATTTAAAGCTGGCGACGTTAAAGCGTTACGTTGAAGCGATGGGA
GGCAAATTAAGCCTAGATGTTGAGCTTCCCACTGGAAAACGAATAGCGTTTAACATTTAG
ATGAGAACATTAGAAGAAGTAATTGCGGCTCAATCACCTGAAAGTCAGGCTATCATCAAAGCTATGGCTGATGAGATGAT
TCTGGAAACAGGACTGCAAATGATGCGTGAAGAATTGCAGCTTTCACAAAAACAGGTTGCTGATGCAATGGGAATCAGCC
AGCCCGCTGTAACTCAACTGGAACAGCGCGGAAATGATTTAAAGCTGGCGACGTTAAAGCGTTACGTTGAAGCGATGGGA
GGCAAATTAAGCCTAGATGTTGAGCTTCCCACTGGAAAACGAATAGCGTTTAACATTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|