Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3109549..3110190 Replicon chromosome
Accession NZ_CP093313
Organism Occallatibacter riparius strain DSM 25168

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag MOP44_RS12550 Protein ID WP_260796379.1
Coordinates 3109549..3109827 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MOP44_RS12555 Protein ID WP_260796380.1
Coordinates 3109840..3110190 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP44_RS12540 (MOP44_12510) 3104831..3107320 + 2490 WP_260796377.1 FecR domain-containing protein -
MOP44_RS12545 (MOP44_12515) 3107478..3109403 + 1926 WP_260796378.1 molecular chaperone DnaK -
MOP44_RS12550 (MOP44_12520) 3109549..3109827 + 279 WP_260796379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOP44_RS12555 (MOP44_12525) 3109840..3110190 + 351 WP_260796380.1 HigA family addiction module antitoxin Antitoxin
MOP44_RS12560 (MOP44_12530) 3110223..3111416 + 1194 WP_260796381.1 DnaJ C-terminal domain-containing protein -
MOP44_RS12565 (MOP44_12535) 3111480..3111884 + 405 WP_260796382.1 helix-turn-helix transcriptional regulator -
MOP44_RS12570 (MOP44_12540) 3111951..3112664 + 714 WP_260796643.1 sulfite exporter TauE/SafE family protein -
MOP44_RS12575 (MOP44_12545) 3112836..3114011 + 1176 WP_260796383.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10914.36 Da        Isoelectric Point: 9.8791

>T238044 WP_260796379.1 NZ_CP093313:3109549-3109827 [Occallatibacter riparius]
MIQTFADTETEALFRTGKSRQWKNIARTAVRRLQALDFASAMEDLKNPPGNRLERLKGDRKGQWSIRINEQFRICFRWDG
KDAWDVEIVDYH

Download         Length: 279 bp

>T238044 NZ_LR890198:c601210-600746 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13138.28 Da        Isoelectric Point: 10.4368

>AT238044 WP_260796380.1 NZ_CP093313:3109840-3110190 [Occallatibacter riparius]
MSIPRKPDERSIPVHPGEFLREDFLTPLGLSANALALALRVPVTRISEIVRERRGITADTALRLARYFGTTPDFWMKMQM
AYDLAVASRESKKRIEVEIFPAPRTESGELKARQIA

Download         Length: 351 bp

>AT238044 NZ_LR890198:c601545-601210 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References