Detailed information of TA system TA237952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2676896..2677398
• Replicon: chromosome
• Accession: NZ_CP093260
• Organism: Moellerella wisconsensis strain W17-3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MNY68_RS11890
• Protein ID: WP_241500949.1
• Coordinates: 2677144..2677398 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MNY68_RS11885
• Protein ID: WP_241500948.1
• Coordinates: 2676896..2677147 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY68_RS11850 (MNY68_11850)	2672851..2673918	+	1068	WP_241540502.1	T6SS immunity protein Tli4 family protein	-
MNY68_RS11855 (MNY68_11855)	2673975..2674070	+	96	WP_241500938.1	T6SS immunity protein Tli4 family protein	-
MNY68_RS11860 (MNY68_11860)	2674112..2674402	+	291	WP_241500939.1	hypothetical protein	-
MNY68_RS11865 (MNY68_11865)	2674399..2674548	+	150	Protein_2302	DUF6392 family protein	-
MNY68_RS11870 (MNY68_11870)	2674742..2675080	+	339	WP_241540503.1	hypothetical protein	-
MNY68_RS11875 (MNY68_11875)	2675704..2676333	+	630	WP_241500946.1	DNA-binding protein	-
MNY68_RS11880 (MNY68_11880)	2676357..2676698	-	342	WP_241540504.1	hypothetical protein	-
MNY68_RS11885 (MNY68_11885)	2676896..2677147	+	252	WP_241500948.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
MNY68_RS11890 (MNY68_11890)	2677144..2677398	+	255	WP_241500949.1	Txe/YoeB family addiction module toxin	Toxin
MNY68_RS11895 (MNY68_11895)	2677576..2677818	+	243	WP_241540505.1	hypothetical protein	-
MNY68_RS11900 (MNY68_11900)	2678357..2678803	+	447	WP_241500951.1	DUF3290 domain-containing protein	-
MNY68_RS11905 (MNY68_11905)	2678812..2679462	+	651	WP_053907799.1	DUF421 domain-containing protein	-
MNY68_RS11910 (MNY68_11910)	2679957..2680892	+	936	WP_241540506.1	Rpn family recombination-promoting nuclease/putative transposase	-
MNY68_RS11915 (MNY68_11915)	2680911..2681114	+	204	WP_241540507.1	hypothetical protein	-
MNY68_RS11920 (MNY68_11920)	2681133..2681324	+	192	WP_241540508.1	hypothetical protein	-
MNY68_RS11925 (MNY68_11925)	2681523..2681915	-	393	WP_047254744.1	SMI1/KNR4 family protein	-
MNY68_RS11930 (MNY68_11930)	2681916..2682149	-	234	WP_241540509.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9926.30 Da
• Isoelectric Point: 9.7120

>T237952 WP_241500949.1 NZ_CP093260:2677144-2677398 [Moellerella wisconsensis]
VKLTWSAEAWEDYLYWQETDRKTVKKINELIKNASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSNDSLLIASC
RYHY

Nucleotide

• Length: 255 bp

>T237952 NZ_LR883013:c93494-93333 [Escherichia coli]
ATGAAACTACCGGGAAACGCCCTTATCTGGTGCGTATTAATCGTGTGCTGCACGTTGTTGATATTCACACTCCTGACCCG
GAATCGCCTGTGCGAAGTCCGGCTGAAGGACGGATACAGGGAAGTTACGGCAACAATGGCTTACGAATCCGGCGGTAAGT
AG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.89 Da
• Isoelectric Point: 5.1367

>AT237952 WP_241500948.1 NZ_CP093260:2676896-2677147 [Moellerella wisconsensis]
MKAVSYSEARQNLSTTMIQTVEDRVPVLITRQNGESCVLMSLDEYNSLEETAYLMRSPKNARRLMDSIESLKDGKGMERE
IIK

Nucleotide

• Length: 252 bp

>AT237952 NZ_LR883013:c93746-93546 [Escherichia coli]
CCCGTGAACTGGCTGAACGACCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGTGTGCAGGTATATGGGCTATGATGTG
CCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACAGTGTTGTGTGGCAGAAGGCAGAAAGCCCCGT
AGTTAATTTTTCATTAACCCACGAGGCCCCCTGTATGTCTA