Detailed information of TA system TA237944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2753662..2754164
• Replicon: chromosome
• Accession: NZ_CP093255
• Organism: Moellerella wisconsensis strain W1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MNY70_RS12185
• Protein ID: WP_241500949.1
• Coordinates: 2753910..2754164 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MNY70_RS12180
• Protein ID: WP_241500948.1
• Coordinates: 2753662..2753913 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY70_RS12160 (MNY70_12160)	2749310..2750302	-	993	WP_241500943.1	T6SS immunity protein Tli4 family protein	-
MNY70_RS12165 (MNY70_12165)	2750406..2752118	-	1713	WP_241544599.1	hypothetical protein	-
MNY70_RS12170 (MNY70_12170)	2752470..2753099	+	630	WP_241500946.1	DNA-binding protein	-
MNY70_RS12175 (MNY70_12175)	2753123..2753464	-	342	WP_241540504.1	hypothetical protein	-
MNY70_RS12180 (MNY70_12180)	2753662..2753913	+	252	WP_241500948.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
MNY70_RS12185 (MNY70_12185)	2753910..2754164	+	255	WP_241500949.1	Txe/YoeB family addiction module toxin	Toxin
MNY70_RS12190 (MNY70_12190)	2754212..2754571	-	360	WP_241543283.1	hypothetical protein	-
MNY70_RS12195 (MNY70_12195)	2755081..2755527	+	447	WP_241500951.1	DUF3290 domain-containing protein	-
MNY70_RS12200 (MNY70_12200)	2755536..2756186	+	651	WP_053907799.1	DUF421 domain-containing protein	-
MNY70_RS12205 (MNY70_12205)	2756681..2757616	+	936	WP_241544600.1	Rpn family recombination-promoting nuclease/putative transposase	-
MNY70_RS12210 (MNY70_12210)	2757635..2757838	+	204	WP_241544601.1	hypothetical protein	-
MNY70_RS12215 (MNY70_12215)	2757857..2758060	+	204	WP_241544601.1	hypothetical protein	-
MNY70_RS12220 (MNY70_12220)	2758079..2758306	+	228	WP_241544602.1	hypothetical protein	-
MNY70_RS12225 (MNY70_12225)	2758325..2758552	+	228	WP_241544602.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9926.30 Da
• Isoelectric Point: 9.7120

>T237944 WP_241500949.1 NZ_CP093255:2753910-2754164 [Moellerella wisconsensis]
VKLTWSAEAWEDYLYWQETDRKTVKKINELIKNASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSNDSLLIASC
RYHY

Nucleotide

• Length: 255 bp

>T237944 NZ_LR883012:c2498063-2497887 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.89 Da
• Isoelectric Point: 5.1367

>AT237944 WP_241500948.1 NZ_CP093255:2753662-2753913 [Moellerella wisconsensis]
MKAVSYSEARQNLSTTMIQTVEDRVPVLITRQNGESCVLMSLDEYNSLEETAYLMRSPKNARRLMDSIESLKDGKGMERE
IIK

Nucleotide

• Length: 252 bp

>AT237944 NZ_LR883012:c2497841-2497425 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA