Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 116740..117391 Replicon plasmid pW18-2-a
Accession NZ_CP093250
Organism Moellerella wisconsensis strain W18-2

Toxin (Protein)


Gene name higB Uniprot ID A0A1B8HBJ1
Locus tag MNY64_RS16730 Protein ID WP_067423956.1
Coordinates 117041..117391 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B8HBM2
Locus tag MNY64_RS16725 Protein ID WP_067423953.1
Coordinates 116740..117039 (-) Length 100 a.a.

Genomic Context

MNY64_RS16685MNY64_RS16690MNY64_RS16695MNY64_RS16700MNY64_RS16705MNY64_RS16715MNY64_RS16735MNY64_RS16740MNY64_RS16745MNY64_RS16750MNY64_RS16670MNY64_RS16675MNY64_RS16680MNY64_RS16710MNY64_RS16720MNY64_RS16725MNY64_RS16730
Location: 113357..113566 (210 bp)
Type: Others
Protein ID: WP_109910748.1
Location: 113643..113957 (315 bp)
Type: Others
Protein ID: WP_082981384.1
Location: 113938..114174 (237 bp)
Type: Others
Protein ID: WP_067423943.1
Location: 114231..114449 (219 bp)
Type: Others
Protein ID: WP_109910747.1
Location: 114483..115007 (525 bp)
Type: Others
Protein ID: WP_067423945.1
Location: 115439..115840 (402 bp)
Type: Others
Protein ID: WP_067423949.1
Location: 117587..118147 (561 bp)
Type: Others
Protein ID: WP_213914584.1
Location: 118689..119591 (903 bp)
Type: Others
Protein ID: WP_241502041.1
Location: 119601..120200 (600 bp)
Type: Others
Protein ID: WP_241543888.1
Location: 120197..120796 (600 bp)
Type: Others
Protein ID: WP_241542955.1
Location: 112040..112340 (301 bp)
Type: Others
Protein ID: Protein_140
Location: 112377..112577 (201 bp)
Type: Others
Protein ID: Protein_141
Location: 112592..113140 (549 bp)
Type: Others
Protein ID: WP_082981383.1
Location: 114961..115338 (378 bp)
Type: Others
Protein ID: WP_109910745.1
Location: 115875..116711 (837 bp)
Type: Others
Protein ID: WP_109910744.1
Location: 116740..117039 (300 bp)
Type: Antitoxin
Protein ID: WP_067423953.1
Location: 117041..117391 (351 bp)
Type: Toxin
Protein ID: WP_067423956.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNY64_RS16670 (MNY64_16680)112040..112340-301Protein_140transposase-
MNY64_RS16675 (MNY64_16685)112377..112577-201Protein_141PAAR domain-containing protein-
MNY64_RS16680 (MNY64_16690)112592..113140-549WP_082981383.1PAAR domain-containing protein-
MNY64_RS16685 (MNY64_16695)113357..113566+210WP_109910748.1hypothetical protein-
MNY64_RS16690 (MNY64_16700)113643..113957+315WP_082981384.1hypothetical protein-
MNY64_RS16695113938..114174+237WP_067423943.1hypothetical protein-
MNY64_RS16700 (MNY64_16705)114231..114449+219WP_109910747.1hypothetical protein-
MNY64_RS16705 (MNY64_16710)114483..115007+525WP_067423945.1hypothetical protein-
MNY64_RS16710114961..115338-378WP_109910745.1hypothetical protein-
MNY64_RS16715 (MNY64_16720)115439..115840+402WP_067423949.1hypothetical protein-
MNY64_RS16720 (MNY64_16725)115875..116711-837WP_109910744.1hypothetical protein-
MNY64_RS16725 (MNY64_16730)116740..117039-300WP_067423953.1helix-turn-helix domain-containing proteinAntitoxin
MNY64_RS16730 (MNY64_16735)117041..117391-351WP_067423956.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MNY64_RS16735 (MNY64_16740)117587..118147+561WP_213914584.1recombinase family protein-
MNY64_RS16740 (MNY64_16745)118689..119591+903WP_241502041.1WYL domain-containing protein-
MNY64_RS16745 (MNY64_16750)119601..120200+600WP_241543888.1DUF1819 family protein-
MNY64_RS16750 (MNY64_16755)120197..120796+600WP_241542955.1DUF1788 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidant(3'')-Ia / lnu(F) / floR / aph(6)-Id / aph(3'')-Ib / sul2 / blaCTX-M-1 / mph(A)-1..270793270793
-flankIS/Tn--117587..118147560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13453.50 Da        Isoelectric Point: 5.2661

>T237942 WP_067423956.1 NZ_CP093250:c117391-117041 [Moellerella wisconsensis]
MWEILTRDLFDSWFEEQNEETQIEVLAVLMILREDGPNLGRPQVDTLKGSQFPNMKELRIQVGGHPIRACFAFDPIRRGI
VLCAGDKKGKDETRFYKKLIKMADAEYSAHLLEQEK

Download         Length: 351 bp

>T237942 NZ_LR883012:2099537-2099640 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10888.61 Da        Isoelectric Point: 8.5841

>AT237942 WP_067423953.1 NZ_CP093250:c117039-116740 [Moellerella wisconsensis]
MSTLNELLAKQSPEALAKIEARAEEIRREITLAKIREELNLSQSELAKSLGVSQPSIAKLENVDNDPKLSTLKRYIKALG
GELSIDVTLPNGKRIGLHL

Download         Length: 300 bp

>AT237942 NZ_LR883012:c2099678-2099407 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B8HBJ1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B8HBM2

References