Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 53169..53893 Replicon plasmid pW18-2-a
Accession NZ_CP093250
Organism Moellerella wisconsensis strain W18-2

Toxin (Protein)


Gene name higB Uniprot ID A0A4D7JCU9
Locus tag MNY64_RS16320 Protein ID WP_067423691.1
Coordinates 53582..53893 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4D7J260
Locus tag MNY64_RS16315 Protein ID WP_067423690.1
Coordinates 53169..53585 (-) Length 139 a.a.

Genomic Context

MNY64_RS16275MNY64_RS16280MNY64_RS16285MNY64_RS16290MNY64_RS16295MNY64_RS16300MNY64_RS16305MNY64_RS16310MNY64_RS16325MNY64_RS16330MNY64_RS16335MNY64_RS16340MNY64_RS16345MNY64_RS16350MNY64_RS16355MNY64_RS16315MNY64_RS16320
Location: 48298..48720 (423 bp)
Type: Others
Protein ID: WP_137022573.1
Location: 48889..49446 (558 bp)
Type: Others
Protein ID: WP_137022574.1
Location: 49585..50154 (570 bp)
Type: Others
Protein ID: WP_241502031.1
Location: 50491..50988 (498 bp)
Type: Others
Protein ID: WP_137022577.1
Location: 51047..51472 (426 bp)
Type: Others
Protein ID: WP_067421875.1
Location: 51536..52312 (777 bp)
Type: Others
Protein ID: WP_067421877.1
Location: 52444..52779 (336 bp)
Type: Others
Protein ID: WP_137022579.1
Location: 52805..53110 (306 bp)
Type: Others
Protein ID: WP_137022580.1
Location: 54064..54630 (567 bp)
Type: Others
Protein ID: WP_067423693.1
Location: 54753..55070 (318 bp)
Type: Others
Protein ID: WP_067423694.1
Location: 55067..55372 (306 bp)
Type: Others
Protein ID: WP_067423696.1
Location: 55678..56550 (873 bp)
Type: Others
Protein ID: WP_235845366.1
Location: 57091..57576 (486 bp)
Type: Others
Protein ID: WP_067423698.1
Location: 57640..58089 (450 bp)
Type: Others
Protein ID: WP_137022583.1
Location: 58260..58742 (483 bp)
Type: Others
Protein ID: WP_137022584.1
Location: 53169..53585 (417 bp)
Type: Antitoxin
Protein ID: WP_067423690.1
Location: 53582..53893 (312 bp)
Type: Toxin
Protein ID: WP_067423691.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNY64_RS16275 (MNY64_16285)48298..48720+423WP_137022573.1hypothetical protein-
MNY64_RS16280 (MNY64_16290)48889..49446+558WP_137022574.1hypothetical protein-
MNY64_RS16285 (MNY64_16295)49585..50154+570WP_241502031.1GDSL-type esterase/lipase family protein-
MNY64_RS16290 (MNY64_16300)50491..50988+498WP_137022577.1hypothetical protein-
MNY64_RS16295 (MNY64_16305)51047..51472+426WP_067421875.1hypothetical protein-
MNY64_RS16300 (MNY64_16310)51536..52312+777WP_067421877.1methyltransferase-
MNY64_RS16305 (MNY64_16315)52444..52779+336WP_137022579.1hypothetical protein-
MNY64_RS16310 (MNY64_16320)52805..53110+306WP_137022580.1hypothetical protein-
MNY64_RS16315 (MNY64_16325)53169..53585-417WP_067423690.1helix-turn-helix domain-containing proteinAntitoxin
MNY64_RS16320 (MNY64_16330)53582..53893-312WP_067423691.1type II toxin-antitoxin system HigB family toxinToxin
MNY64_RS16325 (MNY64_16335)54064..54630+567WP_067423693.1hypothetical protein-
MNY64_RS16330 (MNY64_16340)54753..55070+318WP_067423694.1hypothetical protein-
MNY64_RS16335 (MNY64_16345)55067..55372+306WP_067423696.1hypothetical protein-
MNY64_RS16340 (MNY64_16350)55678..56550+873WP_235845366.1repA protein-
MNY64_RS16345 (MNY64_16355)57091..57576+486WP_067423698.1hypothetical protein-
MNY64_RS16350 (MNY64_16360)57640..58089+450WP_137022583.1hypothetical protein-
MNY64_RS16355 (MNY64_16365)58260..58742+483WP_137022584.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidant(3'')-Ia / lnu(F) / floR / aph(6)-Id / aph(3'')-Ib / sul2 / blaCTX-M-1 / mph(A)-1..270793270793


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12375.16 Da        Isoelectric Point: 10.3654

>T237941 WP_067423691.1 NZ_CP093250:c53893-53582 [Moellerella wisconsensis]
MHVISRDPFNQASKRFPNSAQALSDVYRTLKRDSYQTPDELKKVFPSLDRMKYREKWWVIDISGNALRMMFFADFDRGKI
FVKHITTHAEYDKLTDHYRRTKA

Download         Length: 312 bp

>T237941 NZ_LR883012:1902937-1903191 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15451.44 Da        Isoelectric Point: 4.6155

>AT237941 WP_067423690.1 NZ_CP093250:c53585-53169 [Moellerella wisconsensis]
MMFQDAVKAAQNLVNLVPLLGDSHSRPDYEKAVQLVEHLVENDPDNPLIDMICAKIDAYENAAPEFAEFNQRLAESNDGV
AALRTLMDQYNLNTTDFGNELGSRSYVSRILNGERGLTLEHIKNLSKRFGIPASIFIR

Download         Length: 417 bp

>AT237941 NZ_LR883012:1902689-1902940 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D7JCU9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4D7J260

References