Detailed information of TA system TA237937

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2733067..2733569
• Replicon: chromosome
• Accession: NZ_CP093249
• Organism: Moellerella wisconsensis strain W18-2

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MNY64_RS12145
• Protein ID: WP_241500949.1
• Coordinates: 2733315..2733569 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MNY64_RS12140
• Protein ID: WP_241500948.1
• Coordinates: 2733067..2733318 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY64_RS12120 (MNY64_12125)	2728582..2730102	-	1521	WP_241543282.1	GPI inositol-deacylase	-
MNY64_RS12125 (MNY64_12130)	2730185..2731335	+	1151	WP_241501952.1	IS3 family transposase	-
MNY64_RS12130 (MNY64_12135)	2731875..2732504	+	630	WP_241500946.1	DNA-binding protein	-
MNY64_RS12135 (MNY64_12140)	2732528..2732869	-	342	WP_241540504.1	hypothetical protein	-
MNY64_RS12140 (MNY64_12145)	2733067..2733318	+	252	WP_241500948.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
MNY64_RS12145 (MNY64_12150)	2733315..2733569	+	255	WP_241500949.1	Txe/YoeB family addiction module toxin	Toxin
MNY64_RS12150 (MNY64_12155)	2733617..2733976	-	360	WP_241543283.1	hypothetical protein	-
MNY64_RS12155 (MNY64_12160)	2734486..2734932	+	447	WP_241500951.1	DUF3290 domain-containing protein	-
MNY64_RS12160 (MNY64_12165)	2734941..2735591	+	651	WP_053907799.1	DUF421 domain-containing protein	-
MNY64_RS12165 (MNY64_12170)	2736086..2737033	+	948	WP_241543284.1	Rpn family recombination-promoting nuclease/putative transposase	-
MNY64_RS12170 (MNY64_12175)	2737052..2737255	+	204	WP_241541881.1	hypothetical protein	-
MNY64_RS12175 (MNY64_12180)	2737274..2737549	+	276	WP_241543285.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2730532..2731335	803

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9926.30 Da
• Isoelectric Point: 9.7120

>T237937 WP_241500949.1 NZ_CP093249:2733315-2733569 [Moellerella wisconsensis]
VKLTWSAEAWEDYLYWQETDRKTVKKINELIKNASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSNDSLLIASC
RYHY

Nucleotide

• Length: 255 bp

>T237937 NZ_LR883012:c844292-843918 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9500.89 Da
• Isoelectric Point: 5.1367

>AT237937 WP_241500948.1 NZ_CP093249:2733067-2733318 [Moellerella wisconsensis]
MKAVSYSEARQNLSTTMIQTVEDRVPVLITRQNGESCVLMSLDEYNSLEETAYLMRSPKNARRLMDSIESLKDGKGMERE
IIK

Nucleotide

• Length: 252 bp

>AT237937 NZ_LR883012:c844750-844382 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA