Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 99593..100317 Replicon plasmid pW51-a
Accession NZ_CP093246
Organism Moellerella wisconsensis strain W51

Toxin (Protein)


Gene name higB Uniprot ID A0A4D7JCU9
Locus tag MNY72_RS16460 Protein ID WP_067423691.1
Coordinates 99593..99904 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4D7J260
Locus tag MNY72_RS16465 Protein ID WP_067423690.1
Coordinates 99901..100317 (+) Length 139 a.a.

Genomic Context

MNY72_RS16460MNY72_RS16465MNY72_RS16425MNY72_RS16430MNY72_RS16435MNY72_RS16440MNY72_RS16445MNY72_RS16450MNY72_RS16455MNY72_RS16470MNY72_RS16475MNY72_RS16480MNY72_RS16485MNY72_RS16490MNY72_RS16495MNY72_RS16500MNY72_RS16505
Location: 99593..99904 (312 bp)
Type: Toxin
Protein ID: WP_067423691.1
Location: 99901..100317 (417 bp)
Type: Antitoxin
Protein ID: WP_067423690.1
Location: 94744..95226 (483 bp)
Type: Others
Protein ID: WP_137022584.1
Location: 95397..95846 (450 bp)
Type: Others
Protein ID: WP_137022583.1
Location: 95910..96395 (486 bp)
Type: Others
Protein ID: WP_067423698.1
Location: 96936..97808 (873 bp)
Type: Others
Protein ID: WP_235845366.1
Location: 98114..98419 (306 bp)
Type: Others
Protein ID: WP_067423696.1
Location: 98416..98733 (318 bp)
Type: Others
Protein ID: WP_067423694.1
Location: 98856..99422 (567 bp)
Type: Others
Protein ID: WP_067423693.1
Location: 100376..100681 (306 bp)
Type: Others
Protein ID: WP_137022580.1
Location: 100707..101042 (336 bp)
Type: Others
Protein ID: WP_137022579.1
Location: 101174..101950 (777 bp)
Type: Others
Protein ID: WP_067421877.1
Location: 102014..102439 (426 bp)
Type: Others
Protein ID: WP_067421875.1
Location: 102498..102995 (498 bp)
Type: Others
Protein ID: WP_137022577.1
Location: 103332..103901 (570 bp)
Type: Others
Protein ID: WP_241502031.1
Location: 104040..104597 (558 bp)
Type: Others
Protein ID: WP_137022574.1
Location: 104766..105188 (423 bp)
Type: Others
Protein ID: WP_137022573.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNY72_RS16425 (MNY72_16420)94744..95226-483WP_137022584.1hypothetical protein-
MNY72_RS16430 (MNY72_16425)95397..95846-450WP_137022583.1hypothetical protein-
MNY72_RS16435 (MNY72_16430)95910..96395-486WP_067423698.1hypothetical protein-
MNY72_RS16440 (MNY72_16435)96936..97808-873WP_235845366.1repA protein-
MNY72_RS16445 (MNY72_16440)98114..98419-306WP_067423696.1hypothetical protein-
MNY72_RS16450 (MNY72_16445)98416..98733-318WP_067423694.1hypothetical protein-
MNY72_RS16455 (MNY72_16450)98856..99422-567WP_067423693.1hypothetical protein-
MNY72_RS16460 (MNY72_16455)99593..99904+312WP_067423691.1type II toxin-antitoxin system HigB family toxinToxin
MNY72_RS16465 (MNY72_16460)99901..100317+417WP_067423690.1helix-turn-helix domain-containing proteinAntitoxin
MNY72_RS16470 (MNY72_16465)100376..100681-306WP_137022580.1hypothetical protein-
MNY72_RS16475 (MNY72_16470)100707..101042-336WP_137022579.1hypothetical protein-
MNY72_RS16480 (MNY72_16475)101174..101950-777WP_067421877.1methyltransferase-
MNY72_RS16485 (MNY72_16480)102014..102439-426WP_067421875.1hypothetical protein-
MNY72_RS16490 (MNY72_16485)102498..102995-498WP_137022577.1hypothetical protein-
MNY72_RS16495 (MNY72_16490)103332..103901-570WP_241502031.1GDSL-type esterase/lipase family protein-
MNY72_RS16500 (MNY72_16495)104040..104597-558WP_137022574.1hypothetical protein-
MNY72_RS16505 (MNY72_16500)104766..105188-423WP_137022573.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaac(3)-IIa / aph(3')-Ia / mph(A) / blaCTX-M-1 / sul2 / aph(3'')-Ib / aph(6)-Id / dfrA1 / ant(3'')-Ia / tet(D)-1..270632270632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12375.16 Da        Isoelectric Point: 10.3654

>T237934 WP_067423691.1 NZ_CP093246:99593-99904 [Moellerella wisconsensis]
MHVISRDPFNQASKRFPNSAQALSDVYRTLKRDSYQTPDELKKVFPSLDRMKYREKWWVIDISGNALRMMFFADFDRGKI
FVKHITTHAEYDKLTDHYRRTKA

Download         Length: 312 bp

>T237934 NZ_LR883012:180405-180512 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15451.44 Da        Isoelectric Point: 4.6155

>AT237934 WP_067423690.1 NZ_CP093246:99901-100317 [Moellerella wisconsensis]
MMFQDAVKAAQNLVNLVPLLGDSHSRPDYEKAVQLVEHLVENDPDNPLIDMICAKIDAYENAAPEFAEFNQRLAESNDGV
AALRTLMDQYNLNTTDFGNELGSRSYVSRILNGERGLTLEHIKNLSKRFGIPASIFIR

Download         Length: 417 bp

>AT237934 NZ_LR883012:c180357-180291 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D7JCU9

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4D7J260

References