Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 22008..22659 Replicon plasmid pW51-a
Accession NZ_CP093246
Organism Moellerella wisconsensis strain W51

Toxin (Protein)


Gene name higB Uniprot ID A0A1B8HBJ1
Locus tag MNY72_RS15970 Protein ID WP_067423956.1
Coordinates 22008..22358 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B8HBM2
Locus tag MNY72_RS15975 Protein ID WP_067423953.1
Coordinates 22360..22659 (+) Length 100 a.a.

Genomic Context

MNY72_RS15970MNY72_RS15975MNY72_RS15980MNY72_RS15990MNY72_RS16020MNY72_RS16025MNY72_RS16030MNY72_RS15950MNY72_RS15955MNY72_RS15960MNY72_RS15965MNY72_RS15985MNY72_RS15995MNY72_RS16000MNY72_RS16005MNY72_RS16010MNY72_RS16015
Location: 22008..22358 (351 bp)
Type: Toxin
Protein ID: WP_067423956.1
Location: 22360..22659 (300 bp)
Type: Antitoxin
Protein ID: WP_067423953.1
Location: 22688..23524 (837 bp)
Type: Others
Protein ID: WP_109910744.1
Location: 24061..24438 (378 bp)
Type: Others
Protein ID: WP_109910745.1
Location: 26259..26807 (549 bp)
Type: Others
Protein ID: WP_082981383.1
Location: 26822..27022 (201 bp)
Type: Others
Protein ID: Protein_27
Location: 27059..27359 (301 bp)
Type: Others
Protein ID: Protein_28
Location: 18611..19210 (600 bp)
Type: Others
Protein ID: WP_241542955.1
Location: 19207..19806 (600 bp)
Type: Others
Protein ID: WP_277629383.1
Location: 19816..20718 (903 bp)
Type: Others
Protein ID: WP_241542965.1
Location: 21252..21812 (561 bp)
Type: Others
Protein ID: WP_213914584.1
Location: 23559..23960 (402 bp)
Type: Others
Protein ID: WP_067423949.1
Location: 24392..24916 (525 bp)
Type: Others
Protein ID: WP_067423945.1
Location: 24950..25168 (219 bp)
Type: Others
Protein ID: WP_109910747.1
Location: 25225..25461 (237 bp)
Type: Others
Protein ID: WP_067423943.1
Location: 25442..25756 (315 bp)
Type: Others
Protein ID: WP_082981384.1
Location: 25833..26042 (210 bp)
Type: Others
Protein ID: WP_109910748.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MNY72_RS15950 (MNY72_15945)18611..19210-600WP_241542955.1DUF1788 domain-containing protein-
MNY72_RS15955 (MNY72_15950)19207..19806-600WP_277629383.1DUF1819 family protein-
MNY72_RS15960 (MNY72_15955)19816..20718-903WP_241542965.1WYL domain-containing protein-
MNY72_RS15965 (MNY72_15960)21252..21812-561WP_213914584.1recombinase family protein-
MNY72_RS15970 (MNY72_15965)22008..22358+351WP_067423956.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MNY72_RS15975 (MNY72_15970)22360..22659+300WP_067423953.1helix-turn-helix domain-containing proteinAntitoxin
MNY72_RS15980 (MNY72_15975)22688..23524+837WP_109910744.1hypothetical protein-
MNY72_RS15985 (MNY72_15980)23559..23960-402WP_067423949.1hypothetical protein-
MNY72_RS15990 (MNY72_15985)24061..24438+378WP_109910745.1hypothetical protein-
MNY72_RS15995 (MNY72_15990)24392..24916-525WP_067423945.1hypothetical protein-
MNY72_RS16000 (MNY72_15995)24950..25168-219WP_109910747.1hypothetical protein-
MNY72_RS16005 (MNY72_16000)25225..25461-237WP_067423943.1hypothetical protein-
MNY72_RS16010 (MNY72_16005)25442..25756-315WP_082981384.1hypothetical protein-
MNY72_RS16015 (MNY72_16010)25833..26042-210WP_109910748.1hypothetical protein-
MNY72_RS16020 (MNY72_16015)26259..26807+549WP_082981383.1PAAR domain-containing protein-
MNY72_RS16025 (MNY72_16020)26822..27022+201Protein_27PAAR domain-containing protein-
MNY72_RS16030 (MNY72_16025)27059..27359+301Protein_28transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaac(3)-IIa / aph(3')-Ia / mph(A) / blaCTX-M-1 / sul2 / aph(3'')-Ib / aph(6)-Id / dfrA1 / ant(3'')-Ia / tet(D)-1..270632270632
-flankIS/Tn--21252..21812560


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13453.50 Da        Isoelectric Point: 5.2661

>T237933 WP_067423956.1 NZ_CP093246:22008-22358 [Moellerella wisconsensis]
MWEILTRDLFDSWFEEQNEETQIEVLAVLMILREDGPNLGRPQVDTLKGSQFPNMKELRIQVGGHPIRACFAFDPIRRGI
VLCAGDKKGKDETRFYKKLIKMADAEYSAHLLEQEK

Download         Length: 351 bp

>T237933 NZ_LR883011:7086-7340 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10888.61 Da        Isoelectric Point: 8.5841

>AT237933 WP_067423953.1 NZ_CP093246:22360-22659 [Moellerella wisconsensis]
MSTLNELLAKQSPEALAKIEARAEEIRREITLAKIREELNLSQSELAKSLGVSQPSIAKLENVDNDPKLSTLKRYIKALG
GELSIDVTLPNGKRIGLHL

Download         Length: 300 bp

>AT237933 NZ_LR883011:7337-7579 [Escherichia coli]
ATGACTATCGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B8HBJ1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B8HBM2

References