Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2648751..2649253 Replicon chromosome
Accession NZ_CP093245
Organism Moellerella wisconsensis strain W51

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MNY72_RS11705 Protein ID WP_241500949.1
Coordinates 2648999..2649253 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MNY72_RS11700 Protein ID WP_241500948.1
Coordinates 2648751..2649002 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MNY72_RS11675 (MNY72_11665) 2644598..2645095 - 498 WP_241541874.1 DUF6392 family protein -
MNY72_RS11680 (MNY72_11670) 2645092..2645460 - 369 WP_241541875.1 S-type Pyocin family protein -
MNY72_RS11685 (MNY72_11675) 2645523..2646509 - 987 WP_241541876.1 S-type pyocin domain-containing protein -
MNY72_RS11690 (MNY72_11680) 2646862..2647491 + 630 WP_241500946.1 DNA-binding protein -
MNY72_RS11695 (MNY72_11685) 2647515..2648162 - 648 WP_241541877.1 RES domain-containing protein -
MNY72_RS11700 (MNY72_11690) 2648751..2649002 + 252 WP_241500948.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
MNY72_RS11705 (MNY72_11695) 2648999..2649253 + 255 WP_241500949.1 Txe/YoeB family addiction module toxin Toxin
MNY72_RS11710 (MNY72_11700) 2649301..2649630 - 330 WP_241541878.1 hypothetical protein -
MNY72_RS11715 (MNY72_11705) 2650140..2650586 + 447 WP_241500951.1 DUF3290 domain-containing protein -
MNY72_RS11720 (MNY72_11710) 2650595..2651245 + 651 WP_053907799.1 DUF421 domain-containing protein -
MNY72_RS11725 (MNY72_11715) 2651740..2652687 + 948 WP_241541879.1 Rpn family recombination-promoting nuclease/putative transposase -
MNY72_RS11730 (MNY72_11720) 2652706..2652933 + 228 WP_241541880.1 hypothetical protein -
MNY72_RS11735 (MNY72_11725) 2652952..2653155 + 204 WP_241541881.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9926.30 Da        Isoelectric Point: 9.7120

>T237930 WP_241500949.1 NZ_CP093245:2648999-2649253 [Moellerella wisconsensis]
VKLTWSAEAWEDYLYWQETDRKTVKKINELIKNASRTPFEGKGKPEPLKHNLAGFWSRRITAEHRLVYAVSNDSLLIASC
RYHY

Download         Length: 255 bp

>T237930 NZ_LR883008:48653-48958 [Escherichia coli]
ATGCAGTTTAAGGTTTACGCCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTGCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGCGCCCGACTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATTGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAATGCCATTAACATGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9500.89 Da        Isoelectric Point: 5.1367

>AT237930 WP_241500948.1 NZ_CP093245:2648751-2649002 [Moellerella wisconsensis]
MKAVSYSEARQNLSTTMIQTVEDRVPVLITRQNGESCVLMSLDEYNSLEETAYLMRSPKNARRLMDSIESLKDGKGMERE
IIK

Download         Length: 252 bp

>AT237930 NZ_LR883008:48433-48651 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTACTCAAAGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGAAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References